Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds

Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium... Allium vegetables, such as garlic, have been used for medicinal purposes throughout the recorded history. The known health benefits of Allium vegetables constituents include cardiovascular effects, improvement of the immune function, lowering of blood glucose level, radioprotection, protection against microbial infections, and anti-cancer effects. Initial evidence for the anti-cancer effect of Allium vegetables was provided by population-based case-control studies. Subsequent laboratory studies showed that the Allium vegetable constituents, such as diallyl disulfide, S -allylcysteine, and ajoene can not only offer protection against chemically induced cancer in animal models by altering carcinogen metabolism, but also suppress growth of cancer cells in culture and in vivo by causing cell cycle arrest and apoptosis induction. Suppression of angiogenesis and experimental metastasis by Allium constituents has also been reported. Defining the mechanism by which sulfur compounds derived from Allium vegetables inhibit cancer cell growth has been the topic of intense research in the last two decades. Some Allium vegetable constituents have also entered clinical trials to assess their safety and anti-cancer efficacy. This article summarizes preclinical and limited clinical data to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Letters Elsevier

Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds

Cancer Letters, Volume 269 (2) – Oct 8, 2008

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Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Ireland Ltd
ISSN
0304-3835
D.O.I.
10.1016/j.canlet.2008.05.027
Publisher site
See Article on Publisher Site

Abstract

Allium vegetables, such as garlic, have been used for medicinal purposes throughout the recorded history. The known health benefits of Allium vegetables constituents include cardiovascular effects, improvement of the immune function, lowering of blood glucose level, radioprotection, protection against microbial infections, and anti-cancer effects. Initial evidence for the anti-cancer effect of Allium vegetables was provided by population-based case-control studies. Subsequent laboratory studies showed that the Allium vegetable constituents, such as diallyl disulfide, S -allylcysteine, and ajoene can not only offer protection against chemically induced cancer in animal models by altering carcinogen metabolism, but also suppress growth of cancer cells in culture and in vivo by causing cell cycle arrest and apoptosis induction. Suppression of angiogenesis and experimental metastasis by Allium constituents has also been reported. Defining the mechanism by which sulfur compounds derived from Allium vegetables inhibit cancer cell growth has been the topic of intense research in the last two decades. Some Allium vegetable constituents have also entered clinical trials to assess their safety and anti-cancer efficacy. This article summarizes preclinical and limited clinical data to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers.

Journal

Cancer LettersElsevier

Published: Oct 8, 2008

References

  • Cancer chemoprevention with garlic and its constituents
    Shukla, Y.; Kalra, N.
  • The chemistry of garlic and onions
    Block, E.
  • Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3
    Arunkumar, A.; Vijayababu, M.R.; Srinivasan, N.; Aruldhas, M.M.; Arunakaran, J.
  • The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells
    Wu, X.J.; Kassie, F.; Mersch-Sundermann, V.
  • Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties
    Li, M.; Ciu, J.R.; Ye, Y.; Min, J.M.; Zhang, L.H.; Wang, K.; Gares, M.; Cros, J.; Wright, M.; Leung-Tack, J.
  • Diallyl disulfide induces apoptosis of human colon tumor cells
    Sundaram, S.G.; Milner, J.A.
  • Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells
    Karmakar, S.; Banik, N.L.; Patel, S.J.; Ray, S.K.
  • Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines
    Nakagawa, H.; Tsuta, K.; Kiuchi, K.; Senzaki, H.; Tanaka, K.; Hioki, K.; Tsubura, A.
  • Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines
    Druesne, N.; Pagniez, A.; Mayeur, C.; Thomas, M.; Cherbuy, C.; Duee, P.H.; Martel, P.; Chaumontet, C.
  • Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their inhibitor TIMP-1 by cultured HUVEC cells
    Meyer, K.; Ueberham, E.; Gebhardt, R.
  • Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice
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  • S -Allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions
    Chu, Q.; Lee, D.T.; Tsao, S.W.; Wang, X.; Wong, Y.C.

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