Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection

Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both... •Seven proteins differ between two reovirus stocks.•Differences in sensitivity to interferon depend on both μ2 and λ2 proteins.•Differences in interferon induction depend on both μ2 and λ1 proteins.•Sensitivity to interferon and induction of interferon can be partly separated.•Multiple reovirus proteins are involved in the control of the interferon response. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2018.01.009
Publisher site
See Article on Publisher Site

Abstract

•Seven proteins differ between two reovirus stocks.•Differences in sensitivity to interferon depend on both μ2 and λ2 proteins.•Differences in interferon induction depend on both μ2 and λ1 proteins.•Sensitivity to interferon and induction of interferon can be partly separated.•Multiple reovirus proteins are involved in the control of the interferon response.

Journal

Virus ResearchElsevier

Published: Mar 2, 2018

References

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