Poly(lactic/glycolic acid) (PLGA)-based polymers have been extensively investigated as promising carriers to control the release rates for various types of pharmaceutical agents. In this study, we employed an atomistic molecular dynamics (MD) computation approach to quantify the Flory–Huggins parameters between poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and tetracycline-HCl (TC-HCl) drugs, which can elucidate the thermodynamic stability and the interaction between drugs and PLGA polymers. Thermodynamic analysis regarding the miscibility and the stability of PLA, PGA, TC-HCl phases were then conducted in line with the experimental fabrication of polymer-drug films of two different copolymer ratio products, i.e., 50/50 (PLA/PGA ratio) and 75/25 PLGA samples. Meso-scale computations using phase-field method (PFM) were also conducted to predict the structural evolution of PLGA/TC-HCl systems using the calculated Flory–Huggins parameters. The results show that the surface morphology of PLGA/TC-HCl film can be highly dependent upon the thermodynamic interaction between the polymer and drug phases.
Polymer – Elsevier
Published: Feb 10, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud