Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice☆

Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice☆ This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (ICV) injection of mPP (0.003–3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after ICV injection and continued for 4 h. The intraperitoneal (IP) injection of mPP (0.03–30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after IP injection and continued for 4 h. In the elevated plus maze test, the ICV injection of mPP (0.003–3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice☆

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Inc.
ISSN
0196-9781
DOI
10.1016/S0196-9781(99)00155-2
Publisher site
See Article on Publisher Site

Abstract

This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (ICV) injection of mPP (0.003–3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after ICV injection and continued for 4 h. The intraperitoneal (IP) injection of mPP (0.03–30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after IP injection and continued for 4 h. In the elevated plus maze test, the ICV injection of mPP (0.003–3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice.

Journal

PeptidesElsevier

Published: Dec 1, 1999

References

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