Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods

Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods In this study, thermo-responsive poly(N-isopropyl acrylamide)-g-gold nanorods (PNIPAAm-g-GNRs) were prepared by grafting telechelic PNIPAAm-SH to the GNRs. They were stable in aqueous medium where the GNRs were protected by PNIPAAm chains as revealed by transmission electron microscope. The longitudinal surface plasmon absorbance had a red shift to 810 nm, and the lower critical solution temperature (LCST) of the PNIPAAm was increased to 34.9 °C. After being irradiated by near-IR for 5 min, the PNIPAAm-g-GNRs solution indicated a temperature increment above its LCST. The opto-thermal effect thus could induce the morphology change of the PNIPAAm, which was found to be reversible. Furthermore, the PNIPAAm-g-GNRs had a much lower cytotoxicity than the surfactant-stabilized GNRs. The cell viability of fibroblast after two days of culture could still reach 89.0% relative to the control. Therefore, the PNIPAAm-g-GNRs could be used as drug carriers in which the drug-release could be controlled by remote near-IR. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Polymer Elsevier

Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier Ltd
ISSN
0032-3861
D.O.I.
10.1016/j.polymer.2015.12.047
Publisher site
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Abstract

In this study, thermo-responsive poly(N-isopropyl acrylamide)-g-gold nanorods (PNIPAAm-g-GNRs) were prepared by grafting telechelic PNIPAAm-SH to the GNRs. They were stable in aqueous medium where the GNRs were protected by PNIPAAm chains as revealed by transmission electron microscope. The longitudinal surface plasmon absorbance had a red shift to 810 nm, and the lower critical solution temperature (LCST) of the PNIPAAm was increased to 34.9 °C. After being irradiated by near-IR for 5 min, the PNIPAAm-g-GNRs solution indicated a temperature increment above its LCST. The opto-thermal effect thus could induce the morphology change of the PNIPAAm, which was found to be reversible. Furthermore, the PNIPAAm-g-GNRs had a much lower cytotoxicity than the surfactant-stabilized GNRs. The cell viability of fibroblast after two days of culture could still reach 89.0% relative to the control. Therefore, the PNIPAAm-g-GNRs could be used as drug carriers in which the drug-release could be controlled by remote near-IR.

Journal

PolymerElsevier

Published: Feb 10, 2016

References

  • Langmuir
    Malikova, N.; Pastoriza-Santos, I.; Schierhorn, M.; Kotov, N.A.; Liz-MarzKn, L.M.
  • Langmuir
    Schulz, F.; Vossmeyer, T.; Bastús, N.G.; Weller, H.
  • Langmuir
    Corbierre, M.K.; Cameron, N.S.; Lennox, R.B.

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