Monocyte–macrophage system as targets for immunomodulation by intravenous immunoglobulin

Monocyte–macrophage system as targets for immunomodulation by intravenous immunoglobulin Pooled human intravenous immunoglobulin (IVIg) has been used successfully to treat or ameliorate the clinical manifestations of humoral immune deficiencies, haematological disorders, HIV infection and many other diseases states. However, the mechanism of action of IVIg remains unclear. Several mechanisms of action of IVIg have been proposed. These include Fcγ receptor blockade, accelerated clearance of endogenous pathogenic auto-antibodies, inhibition of components of the complement cascade, neutralization of super-antigens and bacterial toxins as well as anti-cytokine and anti-idiotype effects. A major contributor to host immunity and immune surveillance against infection, tissue or cell damage and malignancy is the monocyte/macrophage system. Monocyte-directed inflammation is a desirable consequence of microbiological or malignant challenge. However, monocyte hyperactivity may contribute to certain pathological conditions. These include the systemic inflammatory response syndrome (SIRS), septic shock, other dysregulated inflammatory disorders and auto-immunity. Novel therapies that can suppress the hyperactive state or correct monocyte/macrophage dysfunction without compromising normal host cell-mediated immunity are desirable. In this review, we discuss the immunomodulatory effects of IVIg focussing particularly upon the monocyte/macrophage system in pertinent disease states. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Blood Reviews Elsevier

Monocyte–macrophage system as targets for immunomodulation by intravenous immunoglobulin

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Ltd
ISSN
0268-960X
eISSN
1532-1681
DOI
10.1054/blre.1999.0121
Publisher site
See Article on Publisher Site

Abstract

Pooled human intravenous immunoglobulin (IVIg) has been used successfully to treat or ameliorate the clinical manifestations of humoral immune deficiencies, haematological disorders, HIV infection and many other diseases states. However, the mechanism of action of IVIg remains unclear. Several mechanisms of action of IVIg have been proposed. These include Fcγ receptor blockade, accelerated clearance of endogenous pathogenic auto-antibodies, inhibition of components of the complement cascade, neutralization of super-antigens and bacterial toxins as well as anti-cytokine and anti-idiotype effects. A major contributor to host immunity and immune surveillance against infection, tissue or cell damage and malignancy is the monocyte/macrophage system. Monocyte-directed inflammation is a desirable consequence of microbiological or malignant challenge. However, monocyte hyperactivity may contribute to certain pathological conditions. These include the systemic inflammatory response syndrome (SIRS), septic shock, other dysregulated inflammatory disorders and auto-immunity. Novel therapies that can suppress the hyperactive state or correct monocyte/macrophage dysfunction without compromising normal host cell-mediated immunity are desirable. In this review, we discuss the immunomodulatory effects of IVIg focussing particularly upon the monocyte/macrophage system in pertinent disease states.

Journal

Blood ReviewsElsevier

Published: Mar 1, 2000

References

  • Intravenous immunoglobulin (IVIg) in the treatment of autoimmune diseases
    Kaveri, S.V.; Dietrich, G.; Hurez, V.; Kazatchkine, D.
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  • Direct evidence for Hageman Factor (Factor XII) activation by bacterial lipopolysaccharides
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  • Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo
    Aukrust, P.; Müller, F.; Nordøy, I.; Haug, C.J.; Frøland, S.S.
  • Lymphokine production induced by streptococcal pyrogenic exotoxin-A is selectively down regulated by pooled human IgG
    Skansén-Saphir, U.; Andersson, J.; Björk, L.; Andersson, U.
  • Immune response associated production of neopterin
    Huber, C.; Batchelor, J.R.; Fuchs, D.
  • Intravenous Immunoglobulin treatment of experimental colitis induced by dextran sulfate sodium in rats
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