Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study

Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study Article history: Bath salts, or synthetic cathinones, have cocaine-like or amphetamine-like properties and induce psy- Received 17 May 2017 choactive effects via their capacity to modulate serotonin (5-HT) and dopamine (DA). Structurally distinct Received in revised form 21 June 2017 synthetic cathinones are continuously being generated to skirt existing drug laws. One example of these Accepted 30 June 2017 modified compounds is cathinone phthalimide (CP), which has already appeared on the global market. Available online 3 July 2017 The lack of toxicological studies on the effects of CP on monoaminergic systems led to the development of the present study in order to generate an acute toxicity profile for CP, and to clarify whether it pri- Keywords: marily affects both dopamine and serotonin, like the synthetic cathinones mephedrone and methylone, Bath salt or primarily affects dopamine, like 3, 4-methylenedioxypyrovalerone (MDPV). For the first time, the tox- Cathinone phthalimide icity profile of CP (10 M–1000 M) is reported. In pheochromocytoma cells, exposure to CP induced Dopamine cell death, and altered mitochondrial function, as well as intracellular DA and 5-HT levels; at the same Serotonin Abbreviations: METH, methamphetamine; DA, dopamine; 5-HT, serotonin; MDPV, 3 4-methylenedioxypyrovalerone; CP, cathinone phthalimide; PMS, phenazine metho- sulfate; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2017.06.059
Publisher site
See Article on Publisher Site

Abstract

Article history: Bath salts, or synthetic cathinones, have cocaine-like or amphetamine-like properties and induce psy- Received 17 May 2017 choactive effects via their capacity to modulate serotonin (5-HT) and dopamine (DA). Structurally distinct Received in revised form 21 June 2017 synthetic cathinones are continuously being generated to skirt existing drug laws. One example of these Accepted 30 June 2017 modified compounds is cathinone phthalimide (CP), which has already appeared on the global market. Available online 3 July 2017 The lack of toxicological studies on the effects of CP on monoaminergic systems led to the development of the present study in order to generate an acute toxicity profile for CP, and to clarify whether it pri- Keywords: marily affects both dopamine and serotonin, like the synthetic cathinones mephedrone and methylone, Bath salt or primarily affects dopamine, like 3, 4-methylenedioxypyrovalerone (MDPV). For the first time, the tox- Cathinone phthalimide icity profile of CP (10 M–1000 M) is reported. In pheochromocytoma cells, exposure to CP induced Dopamine cell death, and altered mitochondrial function, as well as intracellular DA and 5-HT levels; at the same Serotonin Abbreviations: METH, methamphetamine; DA, dopamine; 5-HT, serotonin; MDPV, 3 4-methylenedioxypyrovalerone; CP, cathinone phthalimide; PMS, phenazine metho- sulfate;

Journal

Neuroscience LettersElsevier

Published: Aug 10, 2017

References

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