Article history: The objective of this study was to optimize a novel tocotrienol (TRF)-rich Self Emulsiﬁed Drug Delivery Received 12 November 2011 System (SEDDS). In the ﬁrst part, an unusual phenomenon was investigated. It was observed that by sub- Received in revised form 19 January 2012 ® ® stituting Tween 80 with Cremophor EL in the SEDDS it was possible to emulsify > 55% TRF (by weight of Accepted 24 January 2012 the formulation) into submicron (<200 nm) emulsion. With Tween , only 17.5% of the loaded TRF could Available online 2 February 2012 be emulsiﬁed into crude emulsion. The superiority of Cremophor was attributed to the special arrange- ment of the surfactant at the oil/water interface, which was conﬁrmed by modelling and docking studies. Keywords: In the second part of this study, the composition of the secondary ingredients in the TRF-rich SEDDS were Surfactants optimized by the modiﬁed Multisimplex approach. SEDDS were manufactured at pre-deﬁned step-size Nanoemulsions and tested for their dissolution behavior. Testing was performed sequentially until the optimum compo- Physical characterization sition that can emulsify 50% of the loaded TRF into a stable < 150 nm submicron emulsion was obtained. Tocotrienol Multisimplex Optimization end-point was identiﬁed
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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