Molecular mechanisms underlying cell fate specification in the developing telencephalon

Molecular mechanisms underlying cell fate specification in the developing telencephalon The cellular properties of neural progenitor cells have been best characterized in the telencephalon, the most complex region of the vertebrate brain. In recent years, several transcription factors, including Mash1, Ngn1/2, Pax6 and Emx1/2, and signaling molecules, such as Notch and bone morphogenetic proteins, have emerged as important players in key areas of telencephalic development. These include the specification of positional identity, the proliferation of neural stem cells and their commitment to a neuronal or glial fate, and the differentiation of layer-specific neuronal phenotypes in the cerebral cortex. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Neurobiology Elsevier

Molecular mechanisms underlying cell fate specification in the developing telencephalon

Loading next page...
 
/lp/elsevier/molecular-mechanisms-underlying-cell-fate-specification-in-the-kbBMyvY0gq
Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ltd
ISSN
0959-4388
DOI
10.1016/S0959-4388(02)00286-6
Publisher site
See Article on Publisher Site

Abstract

The cellular properties of neural progenitor cells have been best characterized in the telencephalon, the most complex region of the vertebrate brain. In recent years, several transcription factors, including Mash1, Ngn1/2, Pax6 and Emx1/2, and signaling molecules, such as Notch and bone morphogenetic proteins, have emerged as important players in key areas of telencephalic development. These include the specification of positional identity, the proliferation of neural stem cells and their commitment to a neuronal or glial fate, and the differentiation of layer-specific neuronal phenotypes in the cerebral cortex.

Journal

Current Opinion in NeurobiologyElsevier

Published: Feb 1, 2002

References

  • Specification of neuronal fates in the ventral neural tube
    Briscoe, J.; Ericson, J.
  • Characterization of CNS precursor subtypes and radial glia
    Hartfuss, E.; Galli, R.; Heins, N.; Götz, M.
  • Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
    Henrique, D.; Hirsinger, E.; Adam, J.; Le Roux, I.; Pourque, O.; Ish-Horowicz, D.; Lewis, J.
  • Gliogenesis in the central nervous system
    Lee, J.C.; Mayer-Proschel, M.; Rao, M.S.
  • Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
    Tomita, K.; Moriyoshi, K.; Nakanishi, S.; Guillemot, F.; Kageyama, R.
  • Basic helix-loop-helix genes in neural development
    Lee, J.E.
  • bHLH transcription factors and mammalian neuronal differentiation
    Kageyama, R.; Ishibashi, M.; Takebayashi, K.; Tomita, K.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off