Molecular control of life and death

Molecular control of life and death Recent evidence has shown that two of the three key genes in the programmed cell death pathway of Caenorhabditis elegans, ced-9 (a cell death suppressor) and ced-3 (a cell death inducer), encode proteins that share structural and functional similarities with the mammalian proto-oncogene product Bcl-2 and interleukin-1β converting enzyme, respectively. These findings reveal key molecules that control life and death decisions in vertebrates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Cell Biology Elsevier

Molecular control of life and death

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Abstract

Recent evidence has shown that two of the three key genes in the programmed cell death pathway of Caenorhabditis elegans, ced-9 (a cell death suppressor) and ced-3 (a cell death inducer), encode proteins that share structural and functional similarities with the mammalian proto-oncogene product Bcl-2 and interleukin-1β converting enzyme, respectively. These findings reveal key molecules that control life and death decisions in vertebrates.

Journal

Current Opinion in Cell BiologyElsevier

Published: Jan 1, 1995

References

  • Mechanisms and functions of cell death
    Ellis, RE; Yuan, J; Horvitz, HR
  • Interleukin-1 and interleukin-1 antagonism
    Dinarello, CA
  • Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells
    Sarin, A; Adams, DH; Henkart, PA
  • Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis
    Lazebnik, YA; Cole, SC; Cooke, CA; Nelson, WG; Earnshaw, WC

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