Modulation of alveolar macrophage innate response in proinflammatory-, pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs

Modulation of alveolar macrophage innate response in proinflammatory-, pro-oxidant-, and... Immunobiology 223 (2018) 49–56 Contents lists available at ScienceDirect Immunobiology journal homepage: www.elsevier.com/locate/imbio Research paper Modulation of alveolar macrophage innate response in proinflammatory-, MARK pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs Niket Yadav, Harish Chandra Microbial Pathogenesis and Immunotoxicology Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267- 0056, USA ARTICLE I NFO ABSTRACT Keywords: There is a continuing need for discovering novel primary or adjunct therapeutic agents to treat inflammatory Alveolar macrophages conditions and infections. Natural products have inspired the discovery of several modern therapeutics; how- Inflammation ever, there is a paucity of mechanistic information on their mode of action. This study investigated the ther- LPS apeutic potential and mode of action of corn mint’s(Mentha arvensis) leaf extract (ME) in alveolar macrophages Mycobacterium (AMs) challenged with model pro-inflammatory (LPS), pro- oxidant (LPS or H O ), and infection 2 2 ROS (Mycobacterium) agents and contribution of its dominant constituents rosmarinic acid, L-menthol, and L-men- MAPKs thone. LPS-induced inflammatory response in the murine AM cell line MH-S was significantly reduced in terms of Mint extract pro-inflammatory cytokines (TNF-α, IL-1α) and nitric oxide (NO) when pre- or post-treated with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunobiology Elsevier

Modulation of alveolar macrophage innate response in proinflammatory-, pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier GmbH
ISSN
0171-2985
eISSN
1878-3279
D.O.I.
10.1016/j.imbio.2017.10.015
Publisher site
See Article on Publisher Site

Abstract

Immunobiology 223 (2018) 49–56 Contents lists available at ScienceDirect Immunobiology journal homepage: www.elsevier.com/locate/imbio Research paper Modulation of alveolar macrophage innate response in proinflammatory-, MARK pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs Niket Yadav, Harish Chandra Microbial Pathogenesis and Immunotoxicology Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267- 0056, USA ARTICLE I NFO ABSTRACT Keywords: There is a continuing need for discovering novel primary or adjunct therapeutic agents to treat inflammatory Alveolar macrophages conditions and infections. Natural products have inspired the discovery of several modern therapeutics; how- Inflammation ever, there is a paucity of mechanistic information on their mode of action. This study investigated the ther- LPS apeutic potential and mode of action of corn mint’s(Mentha arvensis) leaf extract (ME) in alveolar macrophages Mycobacterium (AMs) challenged with model pro-inflammatory (LPS), pro- oxidant (LPS or H O ), and infection 2 2 ROS (Mycobacterium) agents and contribution of its dominant constituents rosmarinic acid, L-menthol, and L-men- MAPKs thone. LPS-induced inflammatory response in the murine AM cell line MH-S was significantly reduced in terms of Mint extract pro-inflammatory cytokines (TNF-α, IL-1α) and nitric oxide (NO) when pre- or post-treated with

Journal

ImmunobiologyElsevier

Published: Jan 1, 2018

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