Immunobiology 223 (2018) 49–56 Contents lists available at ScienceDirect Immunobiology journal homepage: www.elsevier.com/locate/imbio Research paper Modulation of alveolar macrophage innate response in proinﬂammatory-, MARK pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs Niket Yadav, Harish Chandra Microbial Pathogenesis and Immunotoxicology Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267- 0056, USA ARTICLE I NFO ABSTRACT Keywords: There is a continuing need for discovering novel primary or adjunct therapeutic agents to treat inﬂammatory Alveolar macrophages conditions and infections. Natural products have inspired the discovery of several modern therapeutics; how- Inﬂammation ever, there is a paucity of mechanistic information on their mode of action. This study investigated the ther- LPS apeutic potential and mode of action of corn mint’s(Mentha arvensis) leaf extract (ME) in alveolar macrophages Mycobacterium (AMs) challenged with model pro-inﬂammatory (LPS), pro- oxidant (LPS or H O ), and infection 2 2 ROS (Mycobacterium) agents and contribution of its dominant constituents rosmarinic acid, L-menthol, and L-men- MAPKs thone. LPS-induced inﬂammatory response in the murine AM cell line MH-S was signiﬁcantly reduced in terms of Mint extract pro-inﬂammatory cytokines (TNF-α, IL-1α) and nitric oxide (NO) when pre- or post-treated with
Immunobiology – Elsevier
Published: Jan 1, 2018
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