Available online at www.sciencedirect.com ScienceDirect Modular protein domains: an engineering approach toward functional biomaterials 1 1,2 Charng-Yu Lin and Julie C Liu Protein domains and peptide sequences are a powerful tool (PEG) , or with natural polymers, such as polysaccharides for conferring speciﬁc functions to engineered biomaterials. . In this review, we focus on biomaterials utilizing protein Protein sequences with a wide variety of functionalities, domains or peptide sequences in recombinant proteins or including structure, bioactivity, protein–protein interactions, composite materials. and stimuli responsiveness, have been identiﬁed, and advances in molecular biology continue to pinpoint new Progress in molecular biology has enabled the facile sequences. Protein domains can be combined to make production of recombinant proteins. Furthermore, matu- recombinant proteins with multiple functionalities. The high ration in large-scale production techniques makes pro- ﬁdelity of the protein translation machinery results in tein-based materials more economically feasible. New exquisite control over the sequence of recombinant proteins techniques such as incorporation of non-canonical amino and the resulting properties of protein-based materials. In acids further expand the possibilities of protein-based this review, we discuss protein domains and peptide biomaterials. sequences in the context of functional protein-based materials, composite materials, and their biological A recombinant
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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