Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats

Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats The modifying effects of dietary administration of ferulic acid (FA) on azoxymethane (AOM)-induced colon carcinogenesis were examined in three experiments with male 344 rats. In the first experiment, the modifying effect of FA on AOM (15 mg/kg body weight, once a week, for 3 weeks)-induced formation of aberrant crypt foci (ACF) was examined in five groups. Numbers of ACF/colon of groups 2 (AOM+250 ppm FA) and 3 (AOM+500 ppm FA) at the termination (5 weeks after the start) were smaller than of group 1 (AOM alone). Those of ACF/cm 2 of group 3 were also smaller than of group 1 ( P <0.05). In the second experiment, a long-term assay for the effects of FA was conducted with seven groups. At the termination (35 weeks), groups 2 and 3 which were given FA during the initiation phase at doses of 250 and 500 ppm, respectively, had lower incidences of colonic carcinomas (23 and 27%, respectively) than group 1 which was given AOM alone (59%; P <0.05). In the third experiment, to determine whether FA could modify the activities of phase II detoxifying enzymes, glutathione S -transferase (GST) and quinone reductase (QR) in liver and colon, 60 rats were gavaged with FA at four doses (0, 25, 50, 100 mg/kg body weight). Dosing of 100 mg/kg significantly elevated GST activity in liver ( P <0.03), and QR activities in liver and colonic mucosa ( P <0.01 and P <0.02, respectively), suggesting that detoxifying enzymes are related to the blocking effect of FA on AOM-induced colon carcinogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Letters Elsevier

Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ireland Ltd
ISSN
0304-3835
D.O.I.
10.1016/S0304-3835(00)00461-4
Publisher site
See Article on Publisher Site

Abstract

The modifying effects of dietary administration of ferulic acid (FA) on azoxymethane (AOM)-induced colon carcinogenesis were examined in three experiments with male 344 rats. In the first experiment, the modifying effect of FA on AOM (15 mg/kg body weight, once a week, for 3 weeks)-induced formation of aberrant crypt foci (ACF) was examined in five groups. Numbers of ACF/colon of groups 2 (AOM+250 ppm FA) and 3 (AOM+500 ppm FA) at the termination (5 weeks after the start) were smaller than of group 1 (AOM alone). Those of ACF/cm 2 of group 3 were also smaller than of group 1 ( P <0.05). In the second experiment, a long-term assay for the effects of FA was conducted with seven groups. At the termination (35 weeks), groups 2 and 3 which were given FA during the initiation phase at doses of 250 and 500 ppm, respectively, had lower incidences of colonic carcinomas (23 and 27%, respectively) than group 1 which was given AOM alone (59%; P <0.05). In the third experiment, to determine whether FA could modify the activities of phase II detoxifying enzymes, glutathione S -transferase (GST) and quinone reductase (QR) in liver and colon, 60 rats were gavaged with FA at four doses (0, 25, 50, 100 mg/kg body weight). Dosing of 100 mg/kg significantly elevated GST activity in liver ( P <0.03), and QR activities in liver and colonic mucosa ( P <0.01 and P <0.02, respectively), suggesting that detoxifying enzymes are related to the blocking effect of FA on AOM-induced colon carcinogenesis.

Journal

Cancer LettersElsevier

Published: Aug 31, 2000

References

  • Diet and carcinogenesis
    Rogers, A.E.; Zeisel, S.; Groopman, J.
  • Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats
    Kawabata, K.; Tanaka, T.; Murakami, T.; Okada, T.; Murai, H.; Hara, A.; Shimizu, M.; Yamada, Y.; Matsunaga, K.; Yoshimi, N.; Sugie, S.; Mori, H.
  • Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
    Bird, R.P.
  • Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats
    Tanaka, T.; Kawabata, K.; Kakumoto, K.; Makita, H.; Mori, H.; Murakami, A.; Kuki, W.; Takahashi, Y.; Yonei, H.; Satoh, K.; Hara, A.; Koshimizu, K.; Ohigashi, H.
  • Modulation by phytochemicals of cytochrome P450-linked enzyme activity
    Teel, R.; Huynh, H.

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