Modifications of head turning and circling movement following sulpiride microinjections into nucleus accumbens in the rat

Modifications of head turning and circling movement following sulpiride microinjections into... The aim of this study was to determine whether a relationship exists between nucleus accumbens D 2 receptors, circling behavior, and its first stage, the head turning. Rats were unilaterally lesioned in the substantia nigra with 6-hydroxydopamine and afterward treated with d -amphetamine IP Following bilateral intraaccumbens microinjections (1, 5, 10 μg/0.5 μl) of sulpiride, a D 2 receptor antagonist. Computer-assisted video analysis allowed the study of some parameters (number of turns, type of turn, head turning duration, degree and speed) characterizing rotatory activity. Sulpiride microinfusion resulted in a dose-dependent decrease of the number of turns and head rotation speed and in a dose-dependent increase of head-turning duration. Two turn types were observed in relation to the animal's position: a large head-to-tail position with a short-diameter turn type following sulpiride microinjection, and a close head-to-tail position in relation to a wide diameter turn type in the control condition (saline). The results show a relationship between head turning parameters, circling behavior, and D 2 receptors in nucleus accumbens, which may be also involved in the regulation of some mechanisms related to sensory-motor integration in the rat. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Bulletin Elsevier

Modifications of head turning and circling movement following sulpiride microinjections into nucleus accumbens in the rat

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0361-9230
eISSN
1873-2747
D.O.I.
10.1016/0361-9230(95)00064-L
Publisher site
See Article on Publisher Site

Abstract

The aim of this study was to determine whether a relationship exists between nucleus accumbens D 2 receptors, circling behavior, and its first stage, the head turning. Rats were unilaterally lesioned in the substantia nigra with 6-hydroxydopamine and afterward treated with d -amphetamine IP Following bilateral intraaccumbens microinjections (1, 5, 10 μg/0.5 μl) of sulpiride, a D 2 receptor antagonist. Computer-assisted video analysis allowed the study of some parameters (number of turns, type of turn, head turning duration, degree and speed) characterizing rotatory activity. Sulpiride microinfusion resulted in a dose-dependent decrease of the number of turns and head rotation speed and in a dose-dependent increase of head-turning duration. Two turn types were observed in relation to the animal's position: a large head-to-tail position with a short-diameter turn type following sulpiride microinjection, and a close head-to-tail position in relation to a wide diameter turn type in the control condition (saline). The results show a relationship between head turning parameters, circling behavior, and D 2 receptors in nucleus accumbens, which may be also involved in the regulation of some mechanisms related to sensory-motor integration in the rat.

Journal

Brain Research BulletinElsevier

Published: Jan 1, 1995

References

  • Complex motor and sensorimotor functions of striatal and accumbens dopamine: Involvement in instrumental behavior processes
    Salamone, J.D.

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