Modification of morphine sensitization by opioid and dopamine receptor antagonists: evaluation by studying ambulation in mice

Modification of morphine sensitization by opioid and dopamine receptor antagonists: evaluation by... The repeated administration of morphine (10 mg/kg s.c.) at 3- to 4-day intervals caused sensitization to its ambulation-in-creasing effect. A μ-opioid receptor antagonist naloxone (0.03–1 mg/kg s.c.), and dopamine D 1 and D 2 receptor antagonists SCH 23390; R -(+)-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1 H -3-benzazepine HCI (0.01–0.1 mg/kg s.c.) and YM-09151-2 (nemonapride); cis-N -(1-benzyl-2-methylpyrrolidin-3-yl-5-chloro-2-methoxy-4-methylaminobenzamide (.003–0.1 mg/kg s.c.), respectively, dose dependently reduced the ambulation increase caused by morphine as well as the sensitization to morphine, when one of them was combined with morphine in the repeated administration. Treatment with SCH 23390 or YM-09151-2, but not naloxone, 3 h after each morphine administration tended to enhance the morphine sensitization. Furthermore, when YM-09151-2 (0.1 mg/kg) was repeatedly administered to the morphine-naive mice 5 times at 3- to 4-day intervals, these mice showed a significant increase in morphine sensitivity. Although the morphine sensitization was partially reversible, repeated (5 times) treatment of the morphine-sensitized mice with SCH 23390 (0.1 mg/kg) resulted in a further enhancement in morphine sensitivity. The same treatment with YM-09151-2 (0.03 and 0.1 mg/kg) tended to increase the sensitivity. These results suggest that, in terms of ambulation in mice, an enhancement of dopaminergic neurotransmission through the agonistic action on μ-opioid receptors is responsible for induction of morphine sensitization. It is also considered that certain changes in the systems mediated by dopamine D 1 and D 2 receptors are involved in the enhancement of the morphine sensitization and for the overall increase in the morphine sensitivity, respectively. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Modification of morphine sensitization by opioid and dopamine receptor antagonists: evaluation by studying ambulation in mice

European Journal of Pharmacology, Volume 275 (3) – Mar 14, 1995

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0014-2999
D.O.I.
10.1016/0014-2999(94)00787-8
Publisher site
See Article on Publisher Site

Abstract

The repeated administration of morphine (10 mg/kg s.c.) at 3- to 4-day intervals caused sensitization to its ambulation-in-creasing effect. A μ-opioid receptor antagonist naloxone (0.03–1 mg/kg s.c.), and dopamine D 1 and D 2 receptor antagonists SCH 23390; R -(+)-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1 H -3-benzazepine HCI (0.01–0.1 mg/kg s.c.) and YM-09151-2 (nemonapride); cis-N -(1-benzyl-2-methylpyrrolidin-3-yl-5-chloro-2-methoxy-4-methylaminobenzamide (.003–0.1 mg/kg s.c.), respectively, dose dependently reduced the ambulation increase caused by morphine as well as the sensitization to morphine, when one of them was combined with morphine in the repeated administration. Treatment with SCH 23390 or YM-09151-2, but not naloxone, 3 h after each morphine administration tended to enhance the morphine sensitization. Furthermore, when YM-09151-2 (0.1 mg/kg) was repeatedly administered to the morphine-naive mice 5 times at 3- to 4-day intervals, these mice showed a significant increase in morphine sensitivity. Although the morphine sensitization was partially reversible, repeated (5 times) treatment of the morphine-sensitized mice with SCH 23390 (0.1 mg/kg) resulted in a further enhancement in morphine sensitivity. The same treatment with YM-09151-2 (0.03 and 0.1 mg/kg) tended to increase the sensitivity. These results suggest that, in terms of ambulation in mice, an enhancement of dopaminergic neurotransmission through the agonistic action on μ-opioid receptors is responsible for induction of morphine sensitization. It is also considered that certain changes in the systems mediated by dopamine D 1 and D 2 receptors are involved in the enhancement of the morphine sensitization and for the overall increase in the morphine sensitivity, respectively.

Journal

European Journal of PharmacologyElsevier

Published: Mar 14, 1995

References

  • Effects of haloperidol on the methamphetamine sensitization: assessment by ambulatory activity in mice
    Kuribara, H.; Uchihashi, Y.

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