MK801—a neuroprotectant in rat hypertensive eyes

MK801—a neuroprotectant in rat hypertensive eyes Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through l -glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrificed 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

MK801—a neuroprotectant in rat hypertensive eyes

Brain Research, Volume 792 (1) – May 4, 1998

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0006-8993
D.O.I.
10.1016/S0006-8993(98)00212-1
Publisher site
See Article on Publisher Site

Abstract

Excitatory synaptic transmission in the mammalian CNS and retina is mainly mediated through l -glutamate. The effect of MK-801, a non-competitive antagonist of the NMDA subtype of glutamate receptor was studied on rat retinal ganglion cells in hypertensive eyes. MK-801 was administered intraperitoneally to the first group, 1 day before the increase, and in the second group, 2 days after the intraocular pressure (IOP) elevation. Phosphate-buffered saline was administered to the control group. Animals were sacrificed 2 and 4 weeks post-IOP increase. The retinal ganglion cells were counted and compared between control (right) and experimental (left) eyes. The data presented here suggests that MK-801 has neuroprotective properties.

Journal

Brain ResearchElsevier

Published: May 4, 1998

References

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