Mitochondrial regulation of apoptotic cell death

Mitochondrial regulation of apoptotic cell death Mitochondria play a decisive role in the regulation of both apoptotic and necrotic cell death. Permeabilization of the outer mitochondrial membrane and subsequent release of intermembrane space proteins are important features of both models of cell death. The mechanisms by which these proteins are released depend presumably on cell type and the nature of stimuli. Of the mechanisms involved, mitochondrial permeability transition appears to be associated mainly with necrosis, whereas the release of caspase activating proteins during early apoptosis is regulated primarily by the Bcl-2 family of proteins. However, there is increasing evidence for interaction and co-operation between these two mechanisms. The multiple mechanisms of mitochondrial permeabilization may explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemico-Biological Interactions Elsevier

Mitochondrial regulation of apoptotic cell death

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Abstract

Mitochondria play a decisive role in the regulation of both apoptotic and necrotic cell death. Permeabilization of the outer mitochondrial membrane and subsequent release of intermembrane space proteins are important features of both models of cell death. The mechanisms by which these proteins are released depend presumably on cell type and the nature of stimuli. Of the mechanisms involved, mitochondrial permeability transition appears to be associated mainly with necrosis, whereas the release of caspase activating proteins during early apoptosis is regulated primarily by the Bcl-2 family of proteins. However, there is increasing evidence for interaction and co-operation between these two mechanisms. The multiple mechanisms of mitochondrial permeabilization may explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells.

Journal

Chemico-Biological InteractionsElsevier

Published: Oct 27, 2006

References

  • Mitochondrial regulation of apoptotic cell death
    Orrenius, S.
  • Mitochondrial control of apoptosis: the role of Cytochrome c
    Cai, J.; Yang, J.; Jones, D.P.
  • Review: nuclear events in apoptosis
    Robertson, J.D.; Orrenius, S.; Zhivotovsky, B.
  • Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells
    Shimizu, S.; Matsuoka, Y.; Shinohara, Y.; Yoneda, Y.; Tsujimoto, Y.
  • Arsenic stimulates release of Cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition
    Bustamante, J.; Nutt, L.; Orrenius, S.; Gogvadze, V.
  • Preservation of mitochondrial structure and function after Bid- or Bax-mediated Cytochrome c release
    von Ahsen, O.; Renken, C.; Perkins, G.; Kluck, R.M.; Bossy-Wetzel, E.; Newmeyer, D.D.
  • Anionic phospholipids are determinants of membrane protein topology
    van Klompenburg, W.; Nilsson, I.; von Heijne, G.; de Kruijff, B.
  • The biosynthesis and functional role of cardiolipin
    Schlame, M.; Rua, D.; Greenberg, M.L.
  • Structure of Cytochrome c complexes with phospholipids as revealed by resonance energy transfer
    Gorbenko, G.P.
  • Loss of molecular interaction between Cytochrome c and cardiolipin due to lipid peroxidation
    Shidoji, Y.; Hayashi, K.; Komura, S.; Ohishi, N.; Yagi, K.
  • Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
    Ricci, J.E.; Gottlieb, R.A.; Green, D.R.
  • Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity
    Robertson, J.D.; Gogvadze, V.; Kropotov, A.; Vakifahmetoglu, H.; Zhivotovsky, B.; Orrenius, S.

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