miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy

miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated... •MiR-23b was frequently downregulated in TBI patients and experimental TBI model.•Overexpression of miR-23b attenuated brain injury in rat model of TBI.•Overexpression of miR-23b improved TBI-induced neurological and cognitive impairmentss.•Overexpression of miR-23b inhibited TBI-induced the activation of neuronal autophagy in the rat hippocampus CA1 region.•Autophagy-related gene, ATG12, was a novel target of miR-23b.•miR-23b improved TBI-induced cognitive impairments by directly targeting ATG12 to suppress neuronal autophagy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2016.09.020
Publisher site
See Article on Publisher Site

Abstract

•MiR-23b was frequently downregulated in TBI patients and experimental TBI model.•Overexpression of miR-23b attenuated brain injury in rat model of TBI.•Overexpression of miR-23b improved TBI-induced neurological and cognitive impairmentss.•Overexpression of miR-23b inhibited TBI-induced the activation of neuronal autophagy in the rat hippocampus CA1 region.•Autophagy-related gene, ATG12, was a novel target of miR-23b.•miR-23b improved TBI-induced cognitive impairments by directly targeting ATG12 to suppress neuronal autophagy.

Journal

Behavioural Brain ResearchElsevier

Published: Mar 15, 2018

References

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