Available online at www.sciencedirect.com ScienceDirect Microﬂuidic techniques for high throughput single cell analysis Amy Reece, Bingzhao Xia, Zhongliang Jiang, Benjamin Noren, Ralph McBride and John Oakey The microfabrication of microﬂuidic control systems and the and their environment . As increasingly sensitive mo- development of increasingly sensitive molecular ampliﬁcation lecular biology tools have been introduced, a new class of tools have enabled the miniaturization of single cells analytical lab-on-a-chip devices, capable of sorting, segmenting, and platforms. Only recently has the throughput of these platforms individually characterizing large numbers of single cells, increased to a level at which populations can be screened at has emerged . the single cell level. Techniques based upon both active and passive manipulation are now capable of discriminating The increasing throughput of microﬂuidic single cell between single cell phenotypes for sorting, diagnostic or analysis technologies has enabled cellular populations prognostic applications in a variety of clinical scenarios. The to be characterized and parsed for heterogeneity , introduction of multiphase microﬂuidics enables the diseased or mutant cells to be isolated , and rare cells segmentation of single cells into biochemically discrete to be selected from complex cellular backgrounds . picoliter environments. The combination of these techniques Techniques
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera