Microfabricated reaction and separation systems

Microfabricated reaction and separation systems Over the past year there have been a number of recent advances in the fields of miniaturized reaction and separation systems, including the construction of fully integrated ‘lab-on-a-chip’ systems. Microreactors, which initially targeted DNA-based reactions such as the polymerase chain reaction, are now used in several other chemical and biochemical assays. Miniaturized separation columns are currently employed for analyzing a wide variety of samples including DNA, RNA, proteins and cells. Although significant advances have been made at the component level, the realization of an integrated analysis system still remains at the early stages of development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Microfabricated reaction and separation systems

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ltd
ISSN
0958-1669
D.O.I.
10.1016/S0958-1669(00)00166-X
Publisher site
See Article on Publisher Site

Abstract

Over the past year there have been a number of recent advances in the fields of miniaturized reaction and separation systems, including the construction of fully integrated ‘lab-on-a-chip’ systems. Microreactors, which initially targeted DNA-based reactions such as the polymerase chain reaction, are now used in several other chemical and biochemical assays. Miniaturized separation columns are currently employed for analyzing a wide variety of samples including DNA, RNA, proteins and cells. Although significant advances have been made at the component level, the realization of an integrated analysis system still remains at the early stages of development.

Journal

Current Opinion in BiotechnologyElsevier

Published: Feb 1, 2001

References

  • Chip-based microsystems for genomic and proteomic analysis
    Sanders, GHW; Manz, A
  • Monolithic integrated microfluidic DNA amplification and capillary electrophoresis analysis system
    Lagally, ET; Simpson, PC; Mathies, RA
  • Micro-microchips: just how small can we go?
    Wilding, P; Kricka, LJ
  • Microchip systems for immunoassay: an integrated immunoreactor with electrophoretic separation for serum theophylline determination
    Chiem, NH; Harrison, DJ
  • The neurochip: a new multielectrode device for stimulating and recording from cultured neurons
    Maher, MP; Pine, J; Wright, J; Tai, YC
  • Surface micropatterning to regulate cell functions
    Ito, Y
  • Current developments in electrophoretic and chromatographic separation methods on microfabricated devices
    Kutter, JP
  • Detection in capillary electrophoresis
    Swinney, K; Bornhorop, DJ
  • Microreactor and electrochemical detectors fabricated using Si and EPON SU-8
    Hostis, EL; Michel, PE; Fiaccabrino, GC; Strike, DJ; Rooij, NF; Koudelka-Hep, M
  • Miniaturized total analysis systems for biological analysis
    Jakeway, SC; Mello, AJ; Russell, EL

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