Microdialysis in mice for drug delivery research

Microdialysis in mice for drug delivery research Intracerebral microdialysis was first performed in the mouse at the end of the 1980s. Most microdialysis studies on mice were confined to neuropharmacology and changes in neurotransmitter concentrations up to 1995, although pharmacological studies were done on other tissues like the skin, kidney and implanted tumors. The use of microdialysis in mice for pharmacokinetic and drug delivery studies owes much to the recent availability of genetically engineered mice, such as mice in which the genes encoding multiple drug resistance have been knocked out. The quantitative microdialysis of blood and various tissue fluids of the mouse is now feasible and the recent development of specific microdialysis devices for use in mice should facilitate its use in these small animals. This review covers the technical aspects of microdialysis in the mouse and includes references to many of the published studies on pharmacokinetics and drug delivery. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Drug Delivery Reviews Elsevier

Microdialysis in mice for drug delivery research

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science B.V.
ISSN
0169-409x
DOI
10.1016/S0169-409X(00)00111-3
Publisher site
See Article on Publisher Site

Abstract

Intracerebral microdialysis was first performed in the mouse at the end of the 1980s. Most microdialysis studies on mice were confined to neuropharmacology and changes in neurotransmitter concentrations up to 1995, although pharmacological studies were done on other tissues like the skin, kidney and implanted tumors. The use of microdialysis in mice for pharmacokinetic and drug delivery studies owes much to the recent availability of genetically engineered mice, such as mice in which the genes encoding multiple drug resistance have been knocked out. The quantitative microdialysis of blood and various tissue fluids of the mouse is now feasible and the recent development of specific microdialysis devices for use in mice should facilitate its use in these small animals. This review covers the technical aspects of microdialysis in the mouse and includes references to many of the published studies on pharmacokinetics and drug delivery.

Journal

Advanced Drug Delivery ReviewsElsevier

Published: Dec 15, 2000

References

  • The use of microdialysis in pharmacokinetics and pharmacodynamics
    Johansen, M.J.; Newman, R.A.; Madden, T.
  • Brain microdialysis in the mouse
    Boschi, G.; Launay, N.; Rips, R.; Scherrmann, J.M.
  • Deficiency of selenium enhances the K + -induced release of dopamine in the striatum of mice
    Watanabe, C.; Kasanuma, Y.; Satoh, H.
  • Inhibition of reinforcing effects of morphine and naloxone-precipitated opioid withdrawal by novel glycine site and uncompetitive NMDA receptor antagonists
    Popik, P.; Mamczarz, J.; Fraczek, M.; Widla, M.; Hesselink, M.; Danysz, W.
  • Oxidative stress is attenuated in mice overexpressing BCL-2
    Bogdanov, M.B.; Ferrante, R.J.; Mueller, G.; Ramos, L.E.; Martinou, J.C.; Beal, M.F.
  • Comparison of dopamine and noradrenaline release in mouse prefrontal cortex, striatum and hippocampus using microdialysis
    Ihalainen, J.A.; Riekkinen, P.; Feenstra, M.G.P.
  • Quantitative determination of endogenous nitric oxide in the mouse skin in vivo by microdialysis
    Andoh, T.; Kuraishi, Y.
  • Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines
    Zamboni, W.C.; Houghton, P.J.; Hulstein, J.L.; Kirstein, M.; Walsh, J.; Cheshire, P.J.; Hanna, S.K.; Danks, M.K.; Stewart, C.F.
  • Simultaneous microdialysis in brain and blood of the mouse: extracellular and intracellular brain colchicine disposition
    Evrard, P.A.; Ragusi, C.; Boschi, G.; Verbeeck, R.K.; Scherrmann, J.M.

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