Microdialysis and drug delivery to the eye

Microdialysis and drug delivery to the eye The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for treatment of ocular diseases. In this paper, we present a discussion of the anatomical and physiological characteristics and limitations present in the eye for microdialysis sampling of endogenous substrates and xenobiotics. To date, over twenty papers describing microdialysis approaches for assessment of ocular drug delivery and endogenous substrate characterization have been published. Although the majority of papers describe sampling of vitreous humor, recent efforts have been directed towards ocular anterior segment sampling using microdialysis. With this approach, an appreciable reduction in animal use has been realized. In addition, simultaneous examination of administered drug and endogenous substrates modulated by the drug is possible with this approach, facilitating construction of ocular pharmacokinetic/pharmacodynamic relationships through use of relevant surrogate markers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Drug Delivery Reviews Elsevier

Microdialysis and drug delivery to the eye

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science B.V.
ISSN
0169-409x
D.O.I.
10.1016/S0169-409X(00)00112-5
Publisher site
See Article on Publisher Site

Abstract

The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for treatment of ocular diseases. In this paper, we present a discussion of the anatomical and physiological characteristics and limitations present in the eye for microdialysis sampling of endogenous substrates and xenobiotics. To date, over twenty papers describing microdialysis approaches for assessment of ocular drug delivery and endogenous substrate characterization have been published. Although the majority of papers describe sampling of vitreous humor, recent efforts have been directed towards ocular anterior segment sampling using microdialysis. With this approach, an appreciable reduction in animal use has been realized. In addition, simultaneous examination of administered drug and endogenous substrates modulated by the drug is possible with this approach, facilitating construction of ocular pharmacokinetic/pharmacodynamic relationships through use of relevant surrogate markers.

Journal

Advanced Drug Delivery ReviewsElsevier

Published: Dec 15, 2000

References

  • The concentration of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog
    Bito, L.; Davson, H.; Levin, E.; Murray, M.; Snider, N.
  • Flow of aqueous humor in humans
    Brubaker, R.F.
  • Microdialysis evaluation of the ocular pharmacokinetics of propranolol in the conscious rabbit
    Rittenhouse, K.D.; Peiffer, R.L.; Pollack, G.M.
  • Systemic delivery of polypeptide drugs through ocular route
    Chiou, G.C.Y.
  • Phase-relationship and mutual effects between circadian rhythms of ocular melatonin and dopamine in the pigeon
    Adachi, A.; Nogi, T.; Ebihara, S.

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