The flavonoid, hesperetin is the aglycone of hesperidin found in sweet oranges, other citrus fruits and some herbs. 2–4 It is the most consumed flavonoid amounting to about 30% of the total intake. 4 Both compounds are associated with beneficial health effects. 2 Biological activities of hesperetin include antioxidant, bone-sparing and lipid-lowering effects. 5 The antioxident property together with the ability to penetrate the blood–brain barrier is suggested to help in neuroprotection against oxidative damage. 6 Hesperetin also plays a significant role in inflammation and cancer inhibition. 2 It is known that the Nuclear Factor-kappa B (NF-κB) found in the cytoplasm promotes inflammation-associated cancer. NF-κB, in addition, activates the genes responsible for inflammation, among others and prevents cancer cell destruction by inactivating tumor suppressor proteins. 7,8 It also plays a major role in the aging process. 9 Animal experiments show the importance of antioxidants as inhibitors of NF-κB. 10 Thus, phytochemicals like flavanoids with such properties may hold promise for cancer prevention, 7 provided that they block specific signal partways which depend on NF-κβ activation to prevent adverse side effects. 10 One such compound is hesperitin. In vitro biological activities of hesperitin are well documented but little is
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Oct 1, 2011
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