Microbial metabolism. Part 13. 1 Metabolites of hesperetin

Microbial metabolism. Part 13. 1 Metabolites of hesperetin The flavonoid, hesperetin is the aglycone of hesperidin found in sweet oranges, other citrus fruits and some herbs. 2–4 It is the most consumed flavonoid amounting to about 30% of the total intake. 4 Both compounds are associated with beneficial health effects. 2 Biological activities of hesperetin include antioxidant, bone-sparing and lipid-lowering effects. 5 The antioxident property together with the ability to penetrate the blood–brain barrier is suggested to help in neuroprotection against oxidative damage. 6 Hesperetin also plays a significant role in inflammation and cancer inhibition. 2 It is known that the Nuclear Factor-kappa B (NF-κB) found in the cytoplasm promotes inflammation-associated cancer. NF-κB, in addition, activates the genes responsible for inflammation, among others and prevents cancer cell destruction by inactivating tumor suppressor proteins. 7,8 It also plays a major role in the aging process. 9 Animal experiments show the importance of antioxidants as inhibitors of NF-κB. 10 Thus, phytochemicals like flavanoids with such properties may hold promise for cancer prevention, 7 provided that they block specific signal partways which depend on NF-κβ activation to prevent adverse side effects. 10 One such compound is hesperitin. In vitro biological activities of hesperitin are well documented but little is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Microbial metabolism. Part 13. 1 Metabolites of hesperetin

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Publisher
Elsevier
Copyright
Copyright © 2011 Elsevier Ltd
ISSN
0960-894x
DOI
10.1016/j.bmcl.2011.08.004
Publisher site
See Article on Publisher Site

Abstract

The flavonoid, hesperetin is the aglycone of hesperidin found in sweet oranges, other citrus fruits and some herbs. 2–4 It is the most consumed flavonoid amounting to about 30% of the total intake. 4 Both compounds are associated with beneficial health effects. 2 Biological activities of hesperetin include antioxidant, bone-sparing and lipid-lowering effects. 5 The antioxident property together with the ability to penetrate the blood–brain barrier is suggested to help in neuroprotection against oxidative damage. 6 Hesperetin also plays a significant role in inflammation and cancer inhibition. 2 It is known that the Nuclear Factor-kappa B (NF-κB) found in the cytoplasm promotes inflammation-associated cancer. NF-κB, in addition, activates the genes responsible for inflammation, among others and prevents cancer cell destruction by inactivating tumor suppressor proteins. 7,8 It also plays a major role in the aging process. 9 Animal experiments show the importance of antioxidants as inhibitors of NF-κB. 10 Thus, phytochemicals like flavanoids with such properties may hold promise for cancer prevention, 7 provided that they block specific signal partways which depend on NF-κβ activation to prevent adverse side effects. 10 One such compound is hesperitin. In vitro biological activities of hesperitin are well documented but little is

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Oct 1, 2011

References

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