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). Conversely, the activation of AMPK by treatment with the pro- longevity diabetes drug metformin (Met) (50 mg/kg/day for 2 wk, intraperitoneal [IP]) significantly reduced blood glucose levels (Fig 4H and S2C Fig ...
dependent [28] and SKN-1/NRF2 is essential for the healthspan benefits of metformin in C. elegans [29], a role for NRF2 as a pro- longevity signalling pathway across phyla is supported. STUDIES OF RARE ...
and longevity (39, 87). Consistent with this, CR increases health span and/or lifespan in model organisms and improves several markers of health in humans (38) (see “Prolonged fasting and caloric/dietary ...
). These data complement advancing technologies to measure DNA methylation at the level of the genome, improvements in metabolomics, and advances in mass spectroscopy that put top–down proteomic approaches ...
the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO ...
of STEMI patients received reperfusion therapy, but 46% still did not. In developing countries, focusing the pre-hospital care in the network should be a major focus of care to improve the DI-DO time along ...
EB , Willett WC , Stampfer MJ , Hu FB . Effect of type 2 diabetes and its duration on the risk of peripheral arterial disease among men . Am J Med 116 : 236 – 240 , 2004 . doi: 10.1016/j.amjmed ...
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