Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina

Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone... The role of presynaptic metabotropic glutamate receptor (mGluR) on the interaction of red- and green-cone signals was investigated in luminosity-type horizontal cell (LHC) of isolated carp retina. It was found that a dim red background could enhance LHC’s light response to green stimulus, and a dim green background was also able to increase the cell’s response to red flash. Such mutual color enhancement was eliminated by application of groups II and III mGluR antagonist ( S )-methyl-4-carboxyphenyl-glycine (MCPG). Furthermore, inhibition of glutamate uptake by using d -aspartate ( d -Asp) or dl- threo-β-hydroxy-aspartic acid (THA) completely blocked the mutual enhancement of color signals in LHC. However, the GABAergic feedback pathway in the outer retina was unnecessarily involved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Bulletin Elsevier

Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina

Brain Research Bulletin, Volume 60 (1) – Apr 15, 2003

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Science Inc.
ISSN
0361-9230
eISSN
1873-2747
D.O.I.
10.1016/S0361-9230(03)00015-7
Publisher site
See Article on Publisher Site

Abstract

The role of presynaptic metabotropic glutamate receptor (mGluR) on the interaction of red- and green-cone signals was investigated in luminosity-type horizontal cell (LHC) of isolated carp retina. It was found that a dim red background could enhance LHC’s light response to green stimulus, and a dim green background was also able to increase the cell’s response to red flash. Such mutual color enhancement was eliminated by application of groups II and III mGluR antagonist ( S )-methyl-4-carboxyphenyl-glycine (MCPG). Furthermore, inhibition of glutamate uptake by using d -aspartate ( d -Asp) or dl- threo-β-hydroxy-aspartic acid (THA) completely blocked the mutual enhancement of color signals in LHC. However, the GABAergic feedback pathway in the outer retina was unnecessarily involved.

Journal

Brain Research BulletinElsevier

Published: Apr 15, 2003

References

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