1 Introduction</h5> Obesity prevalence has nearly doubled worldwide between 1980 and 2008 and still continues to increase. The largest increase in prevalence rates, especially during childhood and adolescence, has been lately seen in the African region as well as Europe  .</P>Almost 10% of the world’s adult population presents with diabetes, with highest prevalence rates in the Eastern Mediterranean region as well as the American region  .</P>Obesity is in general associated with significantly higher all-cause mortality during adulthood  , and obesity during childhood and adolescence has been shown to significantly increase the risk for morbidity and mortality later in life  . Especially visceral obesity, defined as increased waist circumference and accumulation of adipose tissue in the abdomen, significantly increases the risk for cardiovascular or metabolic diseases, starting as soon as during puberty  . However, there is emerging evidence that some obese patients do not have the typical obesity-associated metabolic disorders, such as insulin resistance and glucose intolerance, arterial hypertension, or dyslipidemia. The phenomenon of metabolically healthy obese patients has been described almost 15 years ago  , and prevalence rates for the MHO phenotype have been reported to vary between 10% and 34% [5–9]
Metabolism – Elsevier
Published: Sep 1, 2014
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