1 Introduction</h5> Major depression is highly frequent and disabling with important functional and health consequences, possibly with vital prognosis ( Kessler et al., 2003; Collins et al., 2011 ). Pharmacological treatments currently available contribute to largely improve the depressive symptomatology, mainly by modulating the monoamine systems ( Murrough and Charney, 2012 ). However, the improvement of depressive symptomatology may occur several weeks after the pharmacological administration. This situation makes necessary research in the field, especially to assess drugs capable of modulating systems other than monoamine systems with the aim to shorten the time for obtaining the improvement of depressive symptoms.</P>These last years, ketamine, a N-methyl-D-aspartate (NMDA) glutamate receptor antagonist which may affect the glutamatergic system, has been proposed of major interest in depression since many reports showed a marked antidepressive effect in the very hours following the administration of a single dose ( Stahl, 2013; Ghasemi et al., 2014; Dutta et al., 2015 ). However, these reports included small clinical samples with a great clinical and medical heterogeneity. For example, some studies assessed the ketamine's effects in unipolar samples, others in bipolar samples; some studies reported the ketamine's effects in the hour, others in the 14 days following
Psychiatry Research – Elsevier
Published: Dec 15, 2015
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera