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Mercurimetric determination of chloride in sweat

The analysis of sweat for increased chloride concentration is used to confirm the diagnosis of cystic fibrosis (CF). CF is recognized as a syndrome with a wide spectrum of clinical presentation associated with a defect in the cystic fibrosis transmembrane conductance regulator protein, a protein that normally regulates the electrolyte transport across epithelial membranes. Several hundred mutations of the regulator protein have been identified. Although mutational analysis is available, it is not informative in all cases. Therefore, the sweat test, mainly chloride determination in sweat, remains standard for diagnostic testing [1] . Nowadays, sweat is mostly collected by the Macroduct® collecting system from Wescor® after pilocarpin iontophoresis. To avoid evaporation of sweat while collecting it, the collection time is short (usually 20–30 min) [1] . That is why mostly small volumes below 30 μl are collected, especially in children. This small amount of sweat makes the determination of chloride difficult. Up to now, no method which is based on mercurimetric titration to determine chloride in sweat and adapted to the Macroduct® collecting system is reported. This letter deals with modifications of the determination of chloride in sweat by mercurimetric titration according to Schales and Schales [2] for blood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinica Chimica Acta Elsevier
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