Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists

Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists The present study sought to identify specific opioid receptor subtypes involved in the modulation of reactivation of amnesic or forgotten memory traces by use of a one-trial inhibitory avoidance training procedures in mice. The effects of naloxone, ICI 174,864 (mu and delta opioid receptor antagonists, respectively) and dynorphin (kappa agonist) were investigated. The results indicated that preretention test administration of naloxone (2 mg/kg) or ICI 174,864 (3 mg/kg) attenuated the amnesia and forgetting as indicated by prolongation of step-through latency. On the other hand, the activation of kappa opioid receptors by dynorphin (1 mg/kg) also showed reactivating effects both after amnesia and forgetting. On the basis of the parallelism of the effects for mu and delta opioid receptor antagonists and kappa agonist, and on the finding that all three opioids demonstrated a different degree of reactivation of amnesic and forgotten memory traces, it was concluded that mu, delta, and kappa opioid receptors contribute to the modulation of amnesia and forgetting by independent mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/0091-3057(95)00099-I
Publisher site
See Article on Publisher Site

Abstract

The present study sought to identify specific opioid receptor subtypes involved in the modulation of reactivation of amnesic or forgotten memory traces by use of a one-trial inhibitory avoidance training procedures in mice. The effects of naloxone, ICI 174,864 (mu and delta opioid receptor antagonists, respectively) and dynorphin (kappa agonist) were investigated. The results indicated that preretention test administration of naloxone (2 mg/kg) or ICI 174,864 (3 mg/kg) attenuated the amnesia and forgetting as indicated by prolongation of step-through latency. On the other hand, the activation of kappa opioid receptors by dynorphin (1 mg/kg) also showed reactivating effects both after amnesia and forgetting. On the basis of the parallelism of the effects for mu and delta opioid receptor antagonists and kappa agonist, and on the finding that all three opioids demonstrated a different degree of reactivation of amnesic and forgotten memory traces, it was concluded that mu, delta, and kappa opioid receptors contribute to the modulation of amnesia and forgetting by independent mechanisms.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Dec 1, 1995

References

  • Involvement of hormonal and neuromodulatory systems in the regulation of memory storage
    McGaugh, J.L.
  • Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
    Mucha, R.F.; Herz, A.
  • ICI 174,864, a selective delta opioid antagonist, reverses the learning impairment produced by (leu)enkephalin
    Schulteis, G.; Martinez, J.L.

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