Melatonin receptors in the mammalian suprachiasmatic nucleus

Melatonin receptors in the mammalian suprachiasmatic nucleus BEHAVIOURAL BRAIN RESEARCH ELSEVIER BehaviouralBrain Research73 (1996) 141-147 Margarita L. Dubocovich *, Susan Benloucif, Monica I. Masana Department of Molecular Pharmacology and Biological Chemistry ($215), Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611 USA Keywords: Circadian rhythms; Melatonin; Light; C3H/HeNmouse;c-fos mRNA;Phase shift; Suprachiasmatic nucleus 1. Introduction The hormone melatonin (N-acetyl-5-methoxytryptamine) transduces photoperiodic information and is involved in the regulation of biological rhythms. It is believed to entrain and synchronize circadian rhythms through activation of melatonin receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus, the site of the mammalian circadian pacemaker. In humans, melatonin administration is effective in the treatment of sleep disorders characterized by alterations in circadian rhythmicity. Melatonin is synthesized from serotonin, primarily in the pineal gland, by the sequential action of the enzymes, serotonin N-acetyltransferase and 5-hydroxy-indole-Omethyltransferase [71]. The circadian production of melatonin from the mammalian pineal gland is endogenously controlled by the hypothalamic SCN and is synchronized by environmental light [40,41]. The levels of pineal and circulating melatonin are high during the hours of darkness in a light-dark cycle or during the subjective night in constant dark [40,54,71]. The neuroanatomical pathways of the circadian timing system involved in the circadian regulation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

Melatonin receptors in the mammalian suprachiasmatic nucleus

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0166-4328
DOI
10.1016/0166-4328(96)00086-1
Publisher site
See Article on Publisher Site

Abstract

BEHAVIOURAL BRAIN RESEARCH ELSEVIER BehaviouralBrain Research73 (1996) 141-147 Margarita L. Dubocovich *, Susan Benloucif, Monica I. Masana Department of Molecular Pharmacology and Biological Chemistry ($215), Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611 USA Keywords: Circadian rhythms; Melatonin; Light; C3H/HeNmouse;c-fos mRNA;Phase shift; Suprachiasmatic nucleus 1. Introduction The hormone melatonin (N-acetyl-5-methoxytryptamine) transduces photoperiodic information and is involved in the regulation of biological rhythms. It is believed to entrain and synchronize circadian rhythms through activation of melatonin receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus, the site of the mammalian circadian pacemaker. In humans, melatonin administration is effective in the treatment of sleep disorders characterized by alterations in circadian rhythmicity. Melatonin is synthesized from serotonin, primarily in the pineal gland, by the sequential action of the enzymes, serotonin N-acetyltransferase and 5-hydroxy-indole-Omethyltransferase [71]. The circadian production of melatonin from the mammalian pineal gland is endogenously controlled by the hypothalamic SCN and is synchronized by environmental light [40,41]. The levels of pineal and circulating melatonin are high during the hours of darkness in a light-dark cycle or during the subjective night in constant dark [40,54,71]. The neuroanatomical pathways of the circadian timing system involved in the circadian regulation

Journal

Behavioural Brain ResearchElsevier

Published: Dec 15, 1995

References

  • Melatonin and circadian rhythmicity
    Armstrong, S.M.; Redman, J.R.
  • Failure of pinealectomy or melatonin to alter circadian activity rhythm of the rat
    Cheung, P.W.; McCormack, C.E.
  • Circadian actions of melatonin at the suprachiasmatic nucleus
    Gillette, M.U.; McArthur, A.J.
  • Phase-shifting the human circadian clock using melatonin
    Lewy, A.J.; Ahmed, S.; Sack, R.L.
  • On the nature of the circadian clock in mammals
    Miller, J.D.
  • Neural control of the pineal gland
    Moore, R.Y.
  • Two families of phase-response curves characterize the resetting of the hamster circadian clock
    Smith, R.D.; Turek, F.W.; Takahashi, J.S.

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