International Journal of Pharmaceutics 559 (2019) 393–401 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm Melatonin loaded with bacterial cellulose nanoﬁber by Pickering-emulsion solvent evaporation for enhanced dissolution and bioavailability Yuanyuan Li, Xiuhua Zhao , Yanjie Liu, Jianhang Yang, Qian Zhang, Lingling Wang, Weiwei Wu, Qilei Yang, Bingxue Liu Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, Heilongjiang, China ARTIC L E I NF O ABSTRAC T Keywords: The objective of the present work aimed to explore the potential of bacterial cellulose (BC) for oral delivery of Bacterial cellulose melatonin (MLT), a natural hormone that faces problems of low solubility and oral bioavailability. BC was Melatonin hydrolyzed by sulfuric acid followed by the oxidation to prepare bacterial cellulose nanoﬁber suspension (BCNs). Dissolution Melatonin-loaded bacterial cellulose nanoﬁber suspension (MLT-BCNs) was prepared by emulsion solvent eva- Bioavailability poration method. The properties of freeze-dried BCs and MLT-BCNs were studied by Fluorescence microscopy Pickering-emulsion (FM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), X–ray diﬀraction (XRD), diﬀer- ential scanning calorimetry (DSC) and thermo gravimetric (TG). The results indicated that the ﬁbers in BCNs became short and thin compared with BC, MLT in MLT-BCNs was
International Journal of Pharmaceutics – Elsevier
Published: Mar 25, 2019
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