Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced... Background Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy. Matrix metalloproteinases (MMPs) are regulators of the ECM and can degrade all the components in the matrix. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Pathology Elsevier

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis

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Publisher
Elsevier
Copyright
Copyright © 2006 Elsevier Inc.
ISSN
1054-8807
D.O.I.
10.1016/j.carpath.2005.11.008
Publisher site
See Article on Publisher Site

Abstract

Background Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy. Matrix metalloproteinases (MMPs) are regulators of the ECM and can degrade all the components in the matrix.

Journal

Cardiovascular PathologyElsevier

Published: Mar 1, 2006

References

  • The dynamic interaction of the extracellular matrix in cardiac remodeling
    Goldsmith, EC; Borg, TK
  • Modulation of cardiac myocyte phenotype in vitro by the composition and orientation of the extracellular matrix
    Simpson, DG; Terracio, L; Terracio, M; Price, RL; Turner, DC; Borg, TK
  • Left and right ventricular collagen type I/III ratios and remodeling post-myocardial infarction
    Wei, S; Chow, LT; Shum, IO; Qin, L; Sanderson, JE
  • Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside
    Badorff, C; Knowlton, KU
  • Altered balance between matrix gelatinases (MMP-2 and MMP-9) and their tissue inhibitors in human dilated cardiomyopathy: potential role of MMP-9 in myosin-heavy chain degradation
    Rouet-Benzineb, P; Buhler, JM; Dreyfus, P; Delcourt, A; Dorent, R; Perennec, J; Crozatier, B; Harf, A; Lafuma, C

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