Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress

Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal... The influence of opioid receptor blockade on the developmental and behavioral effects of prenatal stress was studied. Time-mated dams were implanted with minipumps on day 17 of gestation containing vehicle (V) or naltrexone (NTX, 10 mg/kg/day). Noise and light stress was applied on an unpredictable basis, three times a week throughout gestation to half the dams. Maternal NTX completely prevented the reduction in anogenital distance in prenatally stressed (PS) males and restored the growth rate of both sexes. NTX also decreased the anxiety of PS rats in the plus-maze, increased the opioid component of exploration to control levels, but increased anxiety in control males. NTX did not restore the lower saccharin preference in PS females and decreased it in C females. This suggests that some morphological and behavioral changes induced by prenatal stress could result from excess opioid activity induced by maternal stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/0091-3057(94)00289-U
Publisher site
See Article on Publisher Site

Abstract

The influence of opioid receptor blockade on the developmental and behavioral effects of prenatal stress was studied. Time-mated dams were implanted with minipumps on day 17 of gestation containing vehicle (V) or naltrexone (NTX, 10 mg/kg/day). Noise and light stress was applied on an unpredictable basis, three times a week throughout gestation to half the dams. Maternal NTX completely prevented the reduction in anogenital distance in prenatally stressed (PS) males and restored the growth rate of both sexes. NTX also decreased the anxiety of PS rats in the plus-maze, increased the opioid component of exploration to control levels, but increased anxiety in control males. NTX did not restore the lower saccharin preference in PS females and decreased it in C females. This suggests that some morphological and behavioral changes induced by prenatal stress could result from excess opioid activity induced by maternal stress.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 1995

References

  • Naloxone reduces social and exploratory activity in the rat
    File, S.E.
  • The effects of prenatal exposure to predictable or unpredictable stress on early development in the rat
    Fride, E.; Weinstock, M.
  • Opioid-mediation of separation distress in 10 day old rats: Reversal of stress with maternal stimuli
    Kehoe, P.; Blass, E.M.

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