Marine bis-γ-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression

Marine bis-γ-pyrone polypropionates of onchidione family and their effects on the XBP1 gene... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1093–1096 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Marine bis-c-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression a,1 a,1 a a b,⇑ a,⇑ Zhen-Fang Zhou , Xiao-Lu Li , Li-Gong Yao , Jia Li , Margherita Gavagnin , Yue-Wei Guo State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zuchongzhi Road 555 Zhangjiang Hi-Tech Park, Shanghai 201203, China Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy article i nfo abstract Article history: Two additional new members of the onchidione family, 16-epi-onchidione (1) and 4-epi-onchidione (2), Received 30 October 2017 co-occurring with six previously reported bis-c-pyrone polypropionates including onchidione (3), were Revised 6 February 2018 isolated from the marine pulmonate Onchidium sp. Their structures were determined by extensive spec- Accepted 7 February 2018 troscopic analysis and by comparison with 3 and onchidione-related derivatives. The absolute configura- Available online 8 February 2018 tion of 1 was established by X-ray diffraction analysis employing graphite monochromated Cu K radiation (k = 0.71073 Å) with small Flack parameter 0.08. In http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Marine bis-γ-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.010
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1093–1096 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Marine bis-c-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression a,1 a,1 a a b,⇑ a,⇑ Zhen-Fang Zhou , Xiao-Lu Li , Li-Gong Yao , Jia Li , Margherita Gavagnin , Yue-Wei Guo State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zuchongzhi Road 555 Zhangjiang Hi-Tech Park, Shanghai 201203, China Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy article i nfo abstract Article history: Two additional new members of the onchidione family, 16-epi-onchidione (1) and 4-epi-onchidione (2), Received 30 October 2017 co-occurring with six previously reported bis-c-pyrone polypropionates including onchidione (3), were Revised 6 February 2018 isolated from the marine pulmonate Onchidium sp. Their structures were determined by extensive spec- Accepted 7 February 2018 troscopic analysis and by comparison with 3 and onchidione-related derivatives. The absolute configura- Available online 8 February 2018 tion of 1 was established by X-ray diffraction analysis employing graphite monochromated Cu K radiation (k = 0.71073 Å) with small Flack parameter 0.08. In

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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