Many Major CNS Axon Projections Develop Normally in the Absence of Semaphorin III

Many Major CNS Axon Projections Develop Normally in the Absence of Semaphorin III The semaphorins constitute a large gene family of transmembrane and secreted molecules, many of which are expressed in the nervous system. Genetic studies in Drosophila have revealed a role for semaphorins in axon guidance and synapse formation, and several in vitro studies in mice have demonstrated a dramatic chemorepellent effect of semaphorin III (Sema III) on the axons of several populations of neurons. To investigate the function of Sema III during in vivo axon guidance in the mammalian CNS, we studied the development of axonal projections in mutant mice lacking Sema III. Projections were studied for which either the in vitro evidence suggests a role for Sema III in axon guidance (e.g., cerebellar mossy fibers, thalamocortical axons, or cranial motor neurons) or the in vivo expression suggests a role for Sema III in axon guidance (e.g., cerebellar Purkinje cells, neocortex). We find that many major axonal projections, including climbing fiber, mossy fiber, thalamocortical, and basal forebrain projections and cranial nerves, develop normally in the absence of Sema III. Despite its in vitro function and in vivo expression, it appears as if Sema III is not absolutely required for the formation of many major CNS tracts. Such data are consistent with recent models suggesting that axon guidance is controlled by a balance of forces resulting from multiple guidance cues. Our data lead us to suggest that if Sema III functions in part to guide the formation of major axonal projections, then it does so in combination with both other semaphorins and other families of guidance molecules. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Neuroscience Elsevier

Many Major CNS Axon Projections Develop Normally in the Absence of Semaphorin III

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Publisher
Elsevier
Copyright
Copyright © 1998 Academic Press
ISSN
1044-7431
DOI
10.1006/mcne.1998.0687
Publisher site
See Article on Publisher Site

Abstract

The semaphorins constitute a large gene family of transmembrane and secreted molecules, many of which are expressed in the nervous system. Genetic studies in Drosophila have revealed a role for semaphorins in axon guidance and synapse formation, and several in vitro studies in mice have demonstrated a dramatic chemorepellent effect of semaphorin III (Sema III) on the axons of several populations of neurons. To investigate the function of Sema III during in vivo axon guidance in the mammalian CNS, we studied the development of axonal projections in mutant mice lacking Sema III. Projections were studied for which either the in vitro evidence suggests a role for Sema III in axon guidance (e.g., cerebellar mossy fibers, thalamocortical axons, or cranial motor neurons) or the in vivo expression suggests a role for Sema III in axon guidance (e.g., cerebellar Purkinje cells, neocortex). We find that many major axonal projections, including climbing fiber, mossy fiber, thalamocortical, and basal forebrain projections and cranial nerves, develop normally in the absence of Sema III. Despite its in vitro function and in vivo expression, it appears as if Sema III is not absolutely required for the formation of many major CNS tracts. Such data are consistent with recent models suggesting that axon guidance is controlled by a balance of forces resulting from multiple guidance cues. Our data lead us to suggest that if Sema III functions in part to guide the formation of major axonal projections, then it does so in combination with both other semaphorins and other families of guidance molecules.

Journal

Molecular and Cellular NeuroscienceElsevier

Published: Jul 1, 1998

References

  • Early development of the olivocerebellar projection in the fetal rat using CGRP immunocytochemistry
    Chédotal, A.; Sotelo, C.
  • Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1
    Cohen, N.R.; Taylor, J.S.H.; Scott, L.B.; Guillery, R.W.; Soriano, P.; Furley, A.J.W.
  • A novel transmembrane semaphorin can bind c-src
    Eckhardt, F.; Behar, O.; Calautti, E.; Yonezawa, K.; Nishimoto, I.; Fishman, M.C.
  • Mechanisms and molecules that control growth cone guidance
    Goodman, C.S.
  • The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    Püschel, A.W.; Adams, R.H.; Betz, H.

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