1 Introduction</h5> Since the first report of pandemic influenza A(H1N1) 2009 (H1N1pdm09) virus in April 2009, the virus has spread worldwide and caused a pandemic in the 21st century ( Dawood et al., 2009 ). Anti-influenza agents have been widely used for the chemoprophylaxis and treatment during the 2009 H1N1 pandemic. Due to natural resistance of H1N1pdm09 viruses against adamantanes, neuraminidase (NA) inhibitors (NAIs), especially oseltamivir, were broadly used to mitigate morbidity and mortality during the early phase of the pandemic. With the increasing use of antivirals, oseltamivir-resistant mutants emerged rapidly and 11 cases of resistant viruses were detected during the H1N1 pandemic in South Korea ( Shin et al., 2011; Yi et al., 2010 ). The oseltamivir-resistant viral infections were observed mainly in immunocompromised patients treated with antivirals and all the NAI-resistant variants to H1N1pdm09 viruses had H275Y (N1 numbering) substitution at NA gene ( Yi et al., 2010 ).</P>To assess the fitness and transmissibility of the newly identified H1N1pdm09 virus, various mammalian models have been used and the results were similar or different depending on the viruses used ( Itoh et al., 2009; Kwon et al., 2010; Lange et al., 2009; Maines et al., 2009; Munster
Virus Research – Elsevier
Published: Jun 24, 2014
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