Male Breast Cancer: Epidemiology and Risk Factors

Male Breast Cancer: Epidemiology and Risk Factors Male breast cancer is a rare malignancy that accounts for less than 1% of all cancers in men and less than 1% of all breast cancers. But the incidence is rising and in some patient groups reaching 15% over the course of their lives. The major risk factors for the development of male breast cancer include advancing age, hormonal imbalance, radiation exposure, and a family history of breast cancer. Regarding the latter, incidence can be linked to mutations in high- or low-penetrance genes. The most relevant risk factor for the development of male breast cancer is a mutation in the BRCA2 gene. Most cases present late because of a lack of awareness of the existence of such a malignancy in males and ignorance of the related risk factors. Additionally, males with breast cancer are at special risk for developing a second cancer. This in depth review highlights the epidemiology and risk factors for the development of male breast cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Seminars in Oncology Elsevier

Male Breast Cancer: Epidemiology and Risk Factors

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0093-7754
D.O.I.
10.1053/j.seminoncol.2017.11.002
Publisher site
See Article on Publisher Site

Abstract

Male breast cancer is a rare malignancy that accounts for less than 1% of all cancers in men and less than 1% of all breast cancers. But the incidence is rising and in some patient groups reaching 15% over the course of their lives. The major risk factors for the development of male breast cancer include advancing age, hormonal imbalance, radiation exposure, and a family history of breast cancer. Regarding the latter, incidence can be linked to mutations in high- or low-penetrance genes. The most relevant risk factor for the development of male breast cancer is a mutation in the BRCA2 gene. Most cases present late because of a lack of awareness of the existence of such a malignancy in males and ignorance of the related risk factors. Additionally, males with breast cancer are at special risk for developing a second cancer. This in depth review highlights the epidemiology and risk factors for the development of male breast cancer.

Journal

Seminars in OncologyElsevier

Published: Aug 1, 2017

References

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