Acta Biomaterialia 71 (2018) 49–60 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Magnetically actuated mechanical stimuli on Fe O /mineralized collagen 3 4 coatings to enhance osteogenic differentiation of the MC3T3-E1 cells a a a,b a a,⇑ Junjun Zhuang , Suya Lin , Lingqing Dong , Kui Cheng , Wenjian Weng School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China The Afﬁliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China article i nfo abstract Article history: Mechanical stimuli at the bone-implant interface are considered to activate the mechanotransduction Received 23 September 2017 pathway of the cell to improve the initial osseointegration establishment and to guarantee clinical suc- Received in revised form 3 February 2018 cess of the implant. However, control of the mechanical stimuli at the bone–implant interface still Accepted 5 March 2018 remains a challenge. In this study, we have designed a strategy of a magnetically responsive coating Available online 15 March 2018 on which the mechanical stimuli is controlled because of coating deformation under static magnetic ﬁeld (SMF). The iron oxide nanoparticle/mineralized collagen (IOP-MC) coatings were electrochemically code- Keywords: posited on
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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