Acta Biomaterialia 71 (2018) 132–147 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Macrophage involvement affects matrix stiffness-related inﬂuences on cell osteogenesis under three-dimensional culture conditions 1 1 1 ⇑ Xiao-Tao He , Rui-Xin Wu , Xin-Yue Xu , Jia Wang, Yuan Yin, Fa-Ming Chen State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi’an, PR China ar ti c l e i nf o ab stra ct Article history: Accumulating evidence indicates that the physicochemical properties of biomaterials exert profound Received 9 October 2017 inﬂuences on stem cell fate decisions. However, matrix-based regulation selected through in vitro anal- Received in revised form 29 January 2018 yses based on a given cell population do not genuinely reﬂect the in vivo conditions, in which multiple Accepted 12 February 2018 cell types are involved and interact dynamically. This study constitutes the ﬁrst investigation of how Available online 17 February 2018 macrophages (Mus) in stiffness-tunable transglutaminase cross-linked gelatin (TG-gel) affect the osteo- genesis of bone marrow-derived mesenchymal stem cells (BMMSCs). When a
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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