Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

Lung inflammation biomarkers and lung function in children chronically exposed to arsenic Evidence suggests that exposure to arsenic in drinking water during early childhood or in utero has been associated with an increase in respiratory symptoms or diseases in the adulthood, however only a few studies have been carried out during those sensitive windows of exposure. Recently our group demonstrated that the exposure to arsenic during early childhood or in utero in children was associated with impairment in the lung function and suggested that this adverse effect could be due to a chronic inflammation response to the metalloid. Therefore, we designed this cross-sectional study in a cohort of children associating lung inflammatory biomarkers and lung function with urinary As levels. A total of 275 healthy children were partitioned into four study groups according with their arsenic urinary levels. Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry. Fifty eight percent of the studied children were found to have a restrictive spirometric pattern. In the two highest exposed groups, the soluble receptor for advanced glycation end products' (sRAGE) sputum level was significantly lower and matrix metalloproteinase-9 (MMP-9) concentration was higher. When the biomarkers were correlated to the urinary arsenic species, negative associations were found between dimethylarsinic (DMA), monomethylarsonic percentage (%MMA) and dimethylarsinic percentage (%DMA) with sRAGE and positive associations between %DMA with MMP-9 and with the MMP-9/tissue inhibitor of metalloproteinase (TIMP-1) ratio. In conclusion, chronic arsenic exposure of children negatively correlates with sRAGE, and positively correlated with MMP-9 and MMP-9/TIMP-1 levels, and increases the frequency of an abnormal spirometric pattern. Arsenic-induced alterations in inflammatory biomarkers may contribute to the development of restrictive lung diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Toxicology and Applied Pharmacology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier Inc.
ISSN
0041-008x
D.O.I.
10.1016/j.taap.2015.06.001
Publisher site
See Article on Publisher Site

Abstract

Evidence suggests that exposure to arsenic in drinking water during early childhood or in utero has been associated with an increase in respiratory symptoms or diseases in the adulthood, however only a few studies have been carried out during those sensitive windows of exposure. Recently our group demonstrated that the exposure to arsenic during early childhood or in utero in children was associated with impairment in the lung function and suggested that this adverse effect could be due to a chronic inflammation response to the metalloid. Therefore, we designed this cross-sectional study in a cohort of children associating lung inflammatory biomarkers and lung function with urinary As levels. A total of 275 healthy children were partitioned into four study groups according with their arsenic urinary levels. Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry. Fifty eight percent of the studied children were found to have a restrictive spirometric pattern. In the two highest exposed groups, the soluble receptor for advanced glycation end products' (sRAGE) sputum level was significantly lower and matrix metalloproteinase-9 (MMP-9) concentration was higher. When the biomarkers were correlated to the urinary arsenic species, negative associations were found between dimethylarsinic (DMA), monomethylarsonic percentage (%MMA) and dimethylarsinic percentage (%DMA) with sRAGE and positive associations between %DMA with MMP-9 and with the MMP-9/tissue inhibitor of metalloproteinase (TIMP-1) ratio. In conclusion, chronic arsenic exposure of children negatively correlates with sRAGE, and positively correlated with MMP-9 and MMP-9/TIMP-1 levels, and increases the frequency of an abnormal spirometric pattern. Arsenic-induced alterations in inflammatory biomarkers may contribute to the development of restrictive lung diseases.

Journal

Toxicology and Applied PharmacologyElsevier

Published: Sep 1, 2015

References

  • Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production
    Cooper; Myers, T.A.; Rosenberg, M.; Chavez, M.; Hudson, L.G.
  • Environmental arsenic exposure and sputum metalloproteinase concentrations
    Josyula; Poplin, G.S.; Kurzius-Spencer, M.; McClellen, H.E.; Kopplin, M.J.; Sturup, S.; Lantz, R.C.; Burgess, J.L.
  • Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability
    Kumano-Kuramochi, M.; Ohnishi-Kameyama, M.; Xie, Q.; Niimi, S.; Kubota, F.; Komba, S.; Machida, S.
  • Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cells
    Olsen; Liquori, A.E.; Zong, Y.; Lantz, R.C.; Burgess, J.L.; Boitano, S.
  • In utero and early childhood exposure to arsenic decreases lung function in children
    Recio-Vega; Gonzalez-Cortes, T.; Olivas-Calderon, E.; Lantz, R.C.; Gandolfi, A.J.; Gonzalez-De Alba, C.

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