Low molecular weight heparin gels, based on nanoparticles, for topical delivery

Low molecular weight heparin gels, based on nanoparticles, for topical delivery Article history: A commercial suspension of nanoparticles (Eudragit RS 30D) was used to manufacture a gel for topical Received 2 November 2011 ® application. Gels were prepared by mixing a polycationic polymer (Eudragit RS 30D) and a low molec- Received in revised form 20 January 2012 ular weight heparin (LMWH), an antithrombotic agent. Gels formed spontaneously at a ratio of 1:1 as a Accepted 21 January 2012 result of electrostatic interactions between the polyanionic drug and the polycationic polymer. Different Available online 30 January 2012 ® ® types of heparin were used: Bemiparin, Enoxaparin (Lovenox ), Nadroparin (Fraxiparin ) and Tinzaparin (Innohep ). Several LMWH concentrations were tested. Rheological measurements were performed to Keywords: investigate the gel behavior. Gel formation was confirmed by dynamic rheological measurements as the Low molecular weight heparin elastic modulus (G ) was higher than the viscous one (G ). The amount of heparin incorporated into the Gel gel matrix was determined. A maximum of incorporation (100%) was reached using a heparin solution of Topical delivery 600 IU/mL. The release kinetics of LMWH from the gel were also studied. Regardless of the LMWH used Nanoparticles in the formulation, a biphasic release profile was observed. Accordingly, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Low molecular weight heparin gels, based on nanoparticles, for topical delivery

Loading next page...
 
/lp/elsevier/low-molecular-weight-heparin-gels-based-on-nanoparticles-for-topical-V7Zcl0KdwQ
Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.044
Publisher site
See Article on Publisher Site

Abstract

Article history: A commercial suspension of nanoparticles (Eudragit RS 30D) was used to manufacture a gel for topical Received 2 November 2011 ® application. Gels were prepared by mixing a polycationic polymer (Eudragit RS 30D) and a low molec- Received in revised form 20 January 2012 ular weight heparin (LMWH), an antithrombotic agent. Gels formed spontaneously at a ratio of 1:1 as a Accepted 21 January 2012 result of electrostatic interactions between the polyanionic drug and the polycationic polymer. Different Available online 30 January 2012 ® ® types of heparin were used: Bemiparin, Enoxaparin (Lovenox ), Nadroparin (Fraxiparin ) and Tinzaparin (Innohep ). Several LMWH concentrations were tested. Rheological measurements were performed to Keywords: investigate the gel behavior. Gel formation was confirmed by dynamic rheological measurements as the Low molecular weight heparin elastic modulus (G ) was higher than the viscous one (G ). The amount of heparin incorporated into the Gel gel matrix was determined. A maximum of incorporation (100%) was reached using a heparin solution of Topical delivery 600 IU/mL. The release kinetics of LMWH from the gel were also studied. Regardless of the LMWH used Nanoparticles in the formulation, a biphasic release profile was observed. Accordingly,

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial