Article history: A commercial suspension of nanoparticles (Eudragit RS 30D) was used to manufacture a gel for topical Received 2 November 2011 ® application. Gels were prepared by mixing a polycationic polymer (Eudragit RS 30D) and a low molec- Received in revised form 20 January 2012 ular weight heparin (LMWH), an antithrombotic agent. Gels formed spontaneously at a ratio of 1:1 as a Accepted 21 January 2012 result of electrostatic interactions between the polyanionic drug and the polycationic polymer. Different Available online 30 January 2012 ® ® types of heparin were used: Bemiparin, Enoxaparin (Lovenox ), Nadroparin (Fraxiparin ) and Tinzaparin (Innohep ). Several LMWH concentrations were tested. Rheological measurements were performed to Keywords: investigate the gel behavior. Gel formation was conﬁrmed by dynamic rheological measurements as the Low molecular weight heparin elastic modulus (G ) was higher than the viscous one (G ). The amount of heparin incorporated into the Gel gel matrix was determined. A maximum of incorporation (100%) was reached using a heparin solution of Topical delivery 600 IU/mL. The release kinetics of LMWH from the gel were also studied. Regardless of the LMWH used Nanoparticles in the formulation, a biphasic release proﬁle was observed. Accordingly,
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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