Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less toxic than high dose chemotherapy in an autochthonous murine model of breast cancer

Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less... BackgroundImmunotherapies for cancer treatment have demonstrated substantial promise even though toxicities and development of tumor resistance limit their effectiveness. A combinatorial approach using immunotherapy with other treatment modalities may decrease side effects while maintaining maximal therapeutic effect. We aimed to determine if bacterial immunotherapy in combination with a chemotherapeutic would be efficacious and less toxic than conventional chemotherapy in an established, preclinical, autochthonous tumor model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Surgery Elsevier

Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less toxic than high dose chemotherapy in an autochthonous murine model of breast cancer

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0039-6060
D.O.I.
10.1016/j.surg.2017.09.036
Publisher site
See Article on Publisher Site

Abstract

BackgroundImmunotherapies for cancer treatment have demonstrated substantial promise even though toxicities and development of tumor resistance limit their effectiveness. A combinatorial approach using immunotherapy with other treatment modalities may decrease side effects while maintaining maximal therapeutic effect. We aimed to determine if bacterial immunotherapy in combination with a chemotherapeutic would be efficacious and less toxic than conventional chemotherapy in an established, preclinical, autochthonous tumor model.

Journal

SurgeryElsevier

Published: Mar 1, 2018

References

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