Colloids and Surfaces B: Biointerfaces 172 (2018) 464–470 Contents lists available at ScienceDirect Colloids and Surfaces B: Biointerfaces journal homepage: www.elsevier.com/locate/colsurfb Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation eﬃciency and pH responsive release Botao Song Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710069, Shaanxi, People’s Republic of China ARTIC L E I NF O ABSTRAC T Keywords: Drug delivery systems with high drug encapsulation eﬃciency and controlled release are of great importance in Calcium alginate biomedical ﬁelds. Herein, we report an ingenious approach inspired from the lotus leaf possessing the ability of Superhydrophobic strong repellency to water, which enables the rapid fabrication of drug-loaded calcium alginate (Ca-Alg) par- Drug encapsulation eﬃciency ticles with high drug encapsulation eﬃciency and controlled drug delivery. The design is achieved by in- Control release troducing aqueous droplets containing the mixture of dilute sodium alginate solution, dilute calcium chloride solution, and drug onto the superhydrophobic substrate. Due to water evaporation both the concentration of sodium alginate and calcium chloride within the droplets will gradually increase, and the ionic crosslinking 2+ reaction of sodium alginate with Ca
Colloids and Surfaces B: Biointerfaces – Elsevier
Published: Dec 1, 2018
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