Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release

Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation... Colloids and Surfaces B: Biointerfaces 172 (2018) 464–470 Contents lists available at ScienceDirect Colloids and Surfaces B: Biointerfaces journal homepage: www.elsevier.com/locate/colsurfb Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release Botao Song Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710069, Shaanxi, People’s Republic of China ARTIC L E I NF O ABSTRAC T Keywords: Drug delivery systems with high drug encapsulation efficiency and controlled release are of great importance in Calcium alginate biomedical fields. Herein, we report an ingenious approach inspired from the lotus leaf possessing the ability of Superhydrophobic strong repellency to water, which enables the rapid fabrication of drug-loaded calcium alginate (Ca-Alg) par- Drug encapsulation efficiency ticles with high drug encapsulation efficiency and controlled drug delivery. The design is achieved by in- Control release troducing aqueous droplets containing the mixture of dilute sodium alginate solution, dilute calcium chloride solution, and drug onto the superhydrophobic substrate. Due to water evaporation both the concentration of sodium alginate and calcium chloride within the droplets will gradually increase, and the ionic crosslinking 2+ reaction of sodium alginate with Ca http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Colloids and Surfaces B: Biointerfaces Elsevier

Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0927-7765
eISSN
1873-4367
D.O.I.
10.1016/j.colsurfb.2018.09.001
Publisher site
See Article on Publisher Site

Abstract

Colloids and Surfaces B: Biointerfaces 172 (2018) 464–470 Contents lists available at ScienceDirect Colloids and Surfaces B: Biointerfaces journal homepage: www.elsevier.com/locate/colsurfb Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release Botao Song Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710069, Shaanxi, People’s Republic of China ARTIC L E I NF O ABSTRAC T Keywords: Drug delivery systems with high drug encapsulation efficiency and controlled release are of great importance in Calcium alginate biomedical fields. Herein, we report an ingenious approach inspired from the lotus leaf possessing the ability of Superhydrophobic strong repellency to water, which enables the rapid fabrication of drug-loaded calcium alginate (Ca-Alg) par- Drug encapsulation efficiency ticles with high drug encapsulation efficiency and controlled drug delivery. The design is achieved by in- Control release troducing aqueous droplets containing the mixture of dilute sodium alginate solution, dilute calcium chloride solution, and drug onto the superhydrophobic substrate. Due to water evaporation both the concentration of sodium alginate and calcium chloride within the droplets will gradually increase, and the ionic crosslinking 2+ reaction of sodium alginate with Ca

Journal

Colloids and Surfaces B: BiointerfacesElsevier

Published: Dec 1, 2018

References

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