Loss of Setd4 delays radiation-induced thymic lymphoma in mice

Loss of Setd4 delays radiation-induced thymic lymphoma in mice •The Setd4 gene plays a role in tumorigenesis.•Induced Setd4 deletion in adult mice delayed the development of radiation-induced T- lymphomas.•The Setd4 deficient T-lymphomas had distinct CD8/CD4 marker distribution.•Setd4 deletion accelerated the spontaneous lymphoma development but did not alter the radiation induced T-lymphoma in Tp53 deficient mice.•The study suggests Setd4 as a potential target to suppress lymphoma progression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png DNA Repair Elsevier

Loss of Setd4 delays radiation-induced thymic lymphoma in mice

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Publisher
Elsevier
Copyright
Copyright © 2019 The Authors
ISSN
1568-7864
DOI
10.1016/j.dnarep.2019.102754
Publisher site
See Article on Publisher Site

Abstract

•The Setd4 gene plays a role in tumorigenesis.•Induced Setd4 deletion in adult mice delayed the development of radiation-induced T- lymphomas.•The Setd4 deficient T-lymphomas had distinct CD8/CD4 marker distribution.•Setd4 deletion accelerated the spontaneous lymphoma development but did not alter the radiation induced T-lymphoma in Tp53 deficient mice.•The study suggests Setd4 as a potential target to suppress lymphoma progression.

Journal

DNA RepairElsevier

Published: Feb 1, 2020

References

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