Long-lasting change in 5-HT 2A receptor-mediated behavior in rats after a single footshock

Long-lasting change in 5-HT 2A receptor-mediated behavior in rats after a single footshock To investigate the long-term functional change in the 5-HT 2A receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT 2A receptor agent (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0.1–10 mg/kg of DOI, and the maximal response was attenuated by a single footshock given 24 h before. This suggests that there is a decrease in the number of functionally effective 5-HT 2A receptors. The single footshock-induced reduction in head shakes evoked by DOI was observed immediately and 24 h after footshock, and lasted until 1 and 2 weeks after footshock. Because there were no changes in the ( 3 H)ketanserin binding of the frontal cortex 1 week after footshock, decreases in head shakes were not due to the down-regulation of 5-HT 2A receptors evoked by footshock. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Long-lasting change in 5-HT 2A receptor-mediated behavior in rats after a single footshock

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(02)02302-6
Publisher site
See Article on Publisher Site

Abstract

To investigate the long-term functional change in the 5-HT 2A receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT 2A receptor agent (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0.1–10 mg/kg of DOI, and the maximal response was attenuated by a single footshock given 24 h before. This suggests that there is a decrease in the number of functionally effective 5-HT 2A receptors. The single footshock-induced reduction in head shakes evoked by DOI was observed immediately and 24 h after footshock, and lasted until 1 and 2 weeks after footshock. Because there were no changes in the ( 3 H)ketanserin binding of the frontal cortex 1 week after footshock, decreases in head shakes were not due to the down-regulation of 5-HT 2A receptors evoked by footshock.

Journal

European Journal of PharmacologyElsevier

Published: Oct 4, 2002

References

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