To investigate the long-term functional change in the 5-HT 2A receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT 2A receptor agent (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0.1–10 mg/kg of DOI, and the maximal response was attenuated by a single footshock given 24 h before. This suggests that there is a decrease in the number of functionally effective 5-HT 2A receptors. The single footshock-induced reduction in head shakes evoked by DOI was observed immediately and 24 h after footshock, and lasted until 1 and 2 weeks after footshock. Because there were no changes in the ( 3 H)ketanserin binding of the frontal cortex 1 week after footshock, decreases in head shakes were not due to the down-regulation of 5-HT 2A receptors evoked by footshock.
European Journal of Pharmacology – Elsevier
Published: Oct 4, 2002
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