Ligand-Independent Activation of Progestin Receptors in Sexual Receptivity

Ligand-Independent Activation of Progestin Receptors in Sexual Receptivity Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning as ligand-dependent transcription factors. Studies from our laboratory in the past few years have shown that in addition to their cognate ligands, neurotransmitters like dopamine can activate intracellular steroid receptors in a ligand-independent manner. Using biochemical and molecular approaches we have demonstrated that the effects of neurotransmitter dopamine, on reproductive behavior in female rats and mice, occur by means of cross talk between membrane receptors for dopamine and intracellular progestin receptors (PRs). In this article, our studies on the integration of intracellular signaling pathways leading to the activation of PRs and its impact on modulation of reproductive behavior are summarized. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hormones and Behavior Elsevier

Ligand-Independent Activation of Progestin Receptors in Sexual Receptivity

Hormones and Behavior, Volume 40 (2) – Sep 1, 2001

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Publisher
Elsevier
Copyright
Copyright © 2001 Academic Press
ISSN
0018-506X
eISSN
1095-6867
D.O.I.
10.1006/hbeh.2001.1687
Publisher site
See Article on Publisher Site

Abstract

Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning as ligand-dependent transcription factors. Studies from our laboratory in the past few years have shown that in addition to their cognate ligands, neurotransmitters like dopamine can activate intracellular steroid receptors in a ligand-independent manner. Using biochemical and molecular approaches we have demonstrated that the effects of neurotransmitter dopamine, on reproductive behavior in female rats and mice, occur by means of cross talk between membrane receptors for dopamine and intracellular progestin receptors (PRs). In this article, our studies on the integration of intracellular signaling pathways leading to the activation of PRs and its impact on modulation of reproductive behavior are summarized.

Journal

Hormones and BehaviorElsevier

Published: Sep 1, 2001

References

  • Progesterone has rapid and membrane effects in the facilitation of female mouse sexual behavior
    Frye, C.A.; Vongher, J.M.
  • Progesterone receptor function from a behavioral perspective
    Mani, S.K.; Blaustein, J.D.; O' Malley, B.W.
  • Genomic and membrane actions of progesterone: Implications for reproductive physiology and behavior
    Schumacher, M.; Coirini, H.; Robert, F.; Guennoun, R.; El-Etr, M.
  • Molecular mechanisms of action of steroid/thyroid receptor superfamily members
    Tsai, M.-J.; O' Malley

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