Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression and experimental anxiety

Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression... Leptin decreases food intake through actions in the hypothalamus, partly through interactions with neuropeptide Y (NPY). However, NPY also produces behavioral antistress effects mediated inter alia through the amygdala. If leptin generally suppresses NPY function, the utility of leptin-mimics for treatment of obesity might be limited. Here, we therefore compared the effects of intracerebroventricular leptin on hypothalamic and amygdala NPY expression, as well as the respective related behaviors, i.e., feeding and experimental anxiety. Rats were injected intracerebroventricularly with leptin once daily for 6 days. Leptin-treated subjects consumed significantly less chow and had reduced body weight at the end of the treatment period compared to saline-treated controls. This was accompanied by a significant suppression of hypothalamic NPY expression. In contrast, the expression of NPY within the amygdala was unaffected by leptin. In parallel, in an established animal model of anxiety, the elevated plus-maze, no effect of leptin on anxiety-related behaviors was observed. In conclusion, leptin selectively affects the hypothalamic NPY system and its functional outflow, i.e., feeding and endocrine stress responses. Despite modifying endocrine responses, leptin treatment does not affect behavioral measures of experimental anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression and experimental anxiety

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/S0091-3057(01)00678-5
Publisher site
See Article on Publisher Site

Abstract

Leptin decreases food intake through actions in the hypothalamus, partly through interactions with neuropeptide Y (NPY). However, NPY also produces behavioral antistress effects mediated inter alia through the amygdala. If leptin generally suppresses NPY function, the utility of leptin-mimics for treatment of obesity might be limited. Here, we therefore compared the effects of intracerebroventricular leptin on hypothalamic and amygdala NPY expression, as well as the respective related behaviors, i.e., feeding and experimental anxiety. Rats were injected intracerebroventricularly with leptin once daily for 6 days. Leptin-treated subjects consumed significantly less chow and had reduced body weight at the end of the treatment period compared to saline-treated controls. This was accompanied by a significant suppression of hypothalamic NPY expression. In contrast, the expression of NPY within the amygdala was unaffected by leptin. In parallel, in an established animal model of anxiety, the elevated plus-maze, no effect of leptin on anxiety-related behaviors was observed. In conclusion, leptin selectively affects the hypothalamic NPY system and its functional outflow, i.e., feeding and endocrine stress responses. Despite modifying endocrine responses, leptin treatment does not affect behavioral measures of experimental anxiety.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 2002

References

  • The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability
    Kanatani, A; Kanno, T; Ishihara, A; Hata, M; Sakuraba, A; Tanaka, T; Tsuchiya, Y; Mase, T; Fukuroda, T; Fukami, T; Ihara, M
  • Effects of recombinant murine leptin on steroid secretion of dispersed rat adrenocortical cells
    Malendowicz, LK; Nussdorfer, GG; Markowska, A
  • Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions
    Möller, C; Wiklund, L; Sommer, W; Thorsell, A; Heilig, M
  • Amygdalar neuropeptide Y Y-1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test
    Sajdyk, TJ; Vandergriff, MG; Gehlert, DR
  • Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress
    Thorsell, A; Svensson, P; Wiklund, L; Sommer, W; Ekman, R; Heilig, M
  • Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats
    Vettor, R; Zarjevski, N; Cusin, I; Rohner-Jeanrenaud, F; Jeanrenaud, B

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