LEDGF, a survival factor, activates stress-related genes

LEDGF, a survival factor, activates stress-related genes LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Retinal and Eye Research Elsevier

LEDGF, a survival factor, activates stress-related genes

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ltd
ISSN
1350-9462
eISSN
1873-1635
D.O.I.
10.1016/S1350-9462(02)00007-1
Publisher site
See Article on Publisher Site

Abstract

LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.

Journal

Progress in Retinal and Eye ResearchElsevier

Published: May 1, 2002

References

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  • Spatial and temporal dynamics of two alternatively spliced regulatory factor, lens epithelium-derived growth factor (LEDGF/p75) and p52 in the nucleus
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