Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K + channel

Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K + channel To determine whether stimulation of adenosine receptors and opening of ATP-sensitive K + channels were involved in the protective effect of late preconditioning in the rat retina, rats were subjected to 60 min of retinal ischemia, and ischemic preconditioning was achieved by applying 5 min of ischemia 24 h before 60 min of ischemia. In non-preconditioned rats, cell loss in the ganglion cell layer and thinning of the inner plexiform and inner nuclear layer were observed 7 days after 60 min of ischemia. Ischemic preconditioning completely prevented the retinal tissue damage and 8-phenyltheophylline or 5-hydroxydecanoate reduced the protective effect of ischemic preconditioning. Therefore, stimulation of adenosine receptors and opening of ATP-sensitive K + channels might be involved in the mechanism of histological protection by late preconditioning in the retina. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K + channel

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Ltd
ISSN
0014-2999
D.O.I.
10.1016/S0014-2999(01)00938-4
Publisher site
See Article on Publisher Site

Abstract

To determine whether stimulation of adenosine receptors and opening of ATP-sensitive K + channels were involved in the protective effect of late preconditioning in the rat retina, rats were subjected to 60 min of retinal ischemia, and ischemic preconditioning was achieved by applying 5 min of ischemia 24 h before 60 min of ischemia. In non-preconditioned rats, cell loss in the ganglion cell layer and thinning of the inner plexiform and inner nuclear layer were observed 7 days after 60 min of ischemia. Ischemic preconditioning completely prevented the retinal tissue damage and 8-phenyltheophylline or 5-hydroxydecanoate reduced the protective effect of ischemic preconditioning. Therefore, stimulation of adenosine receptors and opening of ATP-sensitive K + channels might be involved in the mechanism of histological protection by late preconditioning in the retina.

Journal

European Journal of PharmacologyElsevier

Published: Apr 20, 2001

References

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