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a dynamic developmental period for both the endogenous nicotinic acetylcholine and cannabinoid systems; for instance, the highest level of CB1 receptor expression is found during this period.11,25,27,28,34 ...
for the behavioural effects of cannabinoids (Howlett et al., 1986). Further studies to examine whether the chronic alcohol-mediated downregulation of brain CB1 receptors has any functional effect on CB1 receptor ...
compounds are agonists of CB1 cannabinoid receptors , and novel pharmacological tools have recently emerged to help elucidate the functional role of eCBs in the modulation of anxiety and HPA axis function ...
-seeking as well as beer-seeking behaviour in rats. The lack of specificity for alcoholic beverages is somewhat perplexing, casting doubt on the possibility that the cannabinoid receptor agonist specifically ...
administration during adolescence on cannabinoid CB1 receptor binding in brain areas . Brain Res 1257 , 25 – 31 . Google Scholar Crossref Search ADS PubMed WorldCat Mechoulam R. Ben-Shabat S. Hanus L. Ligumsky M ...
are lacking , relevant papers from the literature are connected to identify possible mechanisms or phenotypes of interest for future investigation. A primary focus on prenatal cannabinoid exposure is presented ...
in cognition such as the default network (Serra et al. 2014). Although these data point to relevant brain pathologies in DM1, there is a lack of studies investigating the precise cellular and molecular ...
activation of nicotinic (nAchR) and muscarinic (mAchRs) Ach receptors . Low-dose nicotine increases cell excitability in hippocampus (Penton et al., 2011; Szabo et al., 2008) and has been shown to lower ...
neuronal transmission through activation of the presynaptic cannabinoid type‐1 receptor ( CB1 ). Studies from our laboratory have shown that exogenous cannabinoids infer CB1 ‐dependent anticonvulsant activity ...
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